Neuritin 1

Neuritin 1 (NRN1) is a member of neuritin family. Neuritin is a glycosylphosphatidylinositol- anchored protein induced by neural activity. It is expressed in postmitotic-differentiating neurons of the developing nervous system and a population of small-diameter neurons in the dorsal root ganglia and was anterogradely and retrogradely transported. Neuritin message is induced by neuronal activity and by the activity-regulated neurotrophins BDNF, nerve growth factor (NGF) and NT-3. Purified recombinant neuritin promotes neurite outgrowth and arborization in primary embryonic hippocampal and cortical cultures. Thus, neuritin is considered as a downstream effector of activity-induced neurite outgrowth. In clinical, neuritin levels in diabetes were reduced in both dorsal root ganglia and sciatic nerve of rats, and these deficits were reversed in vivo by treatment with NGF. This manipulation of neuritin levels in diabetes may provide a potential target for the therapeutic intervention in the management of neuropathy.

Neuritin 1 Related Areas

Neuroscience>>Neurotrophic Factor & Receptor>>Other Neurotrophic Factors & Receptors>>NRN1

Neuritin 1 Alternative Names

MGC44811, NRN, dJ380B8.2[Homo sapiens]

0710008J23Rik, MGC40786, Nrn, cpg15[Mus musculus]

Summaries for Neuritin 1

Entrez Gene summary for Neuritin 1:

This gene is expressed in postmitotic-differentiating neurons of the developmental nervous system and neuronal structures associated with plasticity in the adult. The expression of this gene can be induced by neural activity and neurotrophins. The encoded protein contains a consensus cleavage signal found in glycosylphoshatidylinositol (GPI)-anchored proteins. In vitro assays demonstrated that this protein promotes neurite outgrowth and arborization, suggesting its role in promoting neuritogenesis

OMIM - description for Neuritin 1:

NRN1 is a glutamate and neurotrophin receptor target gene encoding a neuronal protein that functions extracellularly to modulate neurite outgrowth.

Wikipedia summary for Neuritin 1:

Using a differential screen of a kainate-activated rat hippocampal dentate gyrus library, Naeve et al. (1997) identified a cDNA encoding neuritin. Using the rat coding sequence as probe, they cloned the human homolog from a cortical cDNA library. The deduced 142-amino acid protein contains a 27-amino acid secretory signal peptide at its N terminus and a 27-amino acid GPI signal peptide at its C terminus. The mature rat and human proteins are 100% identical. Northern blot analysis of rat tissues detected a single 1.6-kb transcript predominantly in brain, with highest expression in the dentate gyrus and lowest expression in the striatum. Northern blot and in situ analyses detected expression of neuritin in developing rat brain at embryonic day 15; the level of expression increased throughout embryonic development and postnatally into adulthood. Neuritin was concentrated on neuronal cell bodies and unevenly dispersed along neuritic projections in the nonmyelinated regions of the brain.

Human Neuritin 1 Protein General Information

 

• Protein names: Name: NRN1 Synonyms: NRN
• Sequence length: 142 AA.
• Domain: Signal
• Sequence similarities: Belongs to the neuritin family.
• Subcellular location: Cell membrane; Lipid-anchor › GPI-anchor

General information above from UniProt

Function for Neuritin 1 Protein

UniProtKB:

Promotes neurite outgrowth and especially branching of neuritic processes in primary hippocampal and cortical cells

Genatlas:

• Neuritin 1 promots neurite outgrowth and arborization
• Neuritin 1 is involved in perinecrotic hypoxia

Homology for human Neuritin 1

• homolog to chimpanzee NRN1 (100.00 pc)
• homolog to murine Nrn1 (97.18 pc)