Neurexophilin-1 / NXPH1 Protein

Neurexophilin-1 / NXPH1 Products

Neurexophilin-1 / NXPH1 Protein, Recombinant

Molecule	Species	Description	Cat. No
Neurexophilin-1/NXPH1	Rat	Neurexophilin-1/NXPH1 Protein, Recombinant	80047-R08H

Neurexophilin-1 / NXPH1 cDNA Clone

Molecule	Species	Description	Cat. No
Neurexophilin-1/NXPH1	Human	Homo sapiens Neurexophilin-1/NXPH1 cDNA Clone	HG10855-M
Neurexophilin-1/NXPH1	Mouse	Mouse Neurexophilin-1/NXPH1 cDNA Clone / ORF Clone	MG50865-G
Neurexophilin-1/NXPH1	Rat	Rattus norvegicus Neurexophilin-1/NXPH1 cDNA Clone	RG80047-M

Neurexophilin-1 / NXPH1 Related Areas

Neuroscience>>Synaptic Protein>>Neurexophilin-1/NXPH1

Neurexophilin-1 / NXPH1 Alternative Names

Neurexophilin-1, NXPH1, Nbla00697, NPH1 [Homo sapiens]

Neurexophilin-1, NXPH1, C130005L03Rik [Mus musculus]

Neurexophilin-1 / NXPH1 Background

Neurexophilin-1, or NXPH1 is a secreted glycoprotein, which belongs to the Neurexophilin family. The Neurexophilin family contain at least four genes and resembles a neuropeptide, suggesting a function as an endogenous ligand for alpha-neurexins. The mammalian brains contain four genes for neurexophilins the products of which share a common structure composed of five domains: an N-terminal signal peptide, a variable N-terminal domain, a highly conserved central domain that is N-glycosylated, a short linker region, and a conserved C-terminal domain that is cysteine-rich. Neurexophilin-1 constitutes a secreted cysteine-rich glycoprotein, forms a very tight complex with alpha neurexins, a group of proteins that promote adhesion between dendrites and axons. Neurexophilins 1 and 3 but not 4 (neurexophilin 2 is not expressed in rodents) bind to a single individual LNS domain, the second overall LNS domain in all three alpha-neurexins.

Neurexophilin-1 / NXPH1 Related Studies

1. Missler M, et al. (1998) Neurexophilin binding to alpha-neurexins. A single LNS domain functions as an independently folding ligand-binding unit. J Biol Chem. 273(52): 34716-23.
2. Missler M, et al. (1998) Neurexophilins form a conserved family of neuropeptide-like glycoproteins. J Neurosci. 18(10): 3630-8.
3. Petrenko AG, et al. (1996) Structure and evolution of neurexophilin. J Neurosci. 16(14): 4360-9.