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Neural Stem Cell (NSC) Marker

Sino Biological offers a comprehensive set of tools for Neural Stem Cell related studies including active proteins, antibodies and cDNA clones.

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    Neural Stem Cell (NSC) Marker Background

    Neural stem cells (NSCs) are multipotent stem cells that are capable of self-renewing and differentiating into the three main central nervous system (CNS) lineages: neurons, astrocytes, and oligodendrocytes. Neural stem cells were first isolated from the neurogenic areas of adult mice brain tissue by Reynolds and Weiss in 1992. Since then, neural stem cells have been isolated from various areas of the adult brain, including non-neurogenic areas, such as the spinal cord, and from various species including human. Neural stem cells undergo proliferative symmetric and asymmetric divisions to replenish themselves and to produce intermediate neural progenitors (INPs), respectively. Intermediate neural progenitors, which reside next to the ventricular zone in the subventricular zone (SVZ), are thought to produce a majority of cortical neurons. Neurons are also produced by neural stem cells undergoing neurogenic asymmetric divisions. Thus, a balance of symmetric and asymmetric neural stem cell divisions regulates the number of neural stem cells, intermediate neural progenitors and produced neurons, and is critical for defining the adult brain.

    Neural Stem Cell (NSC) Marker References

      1. Gage FH. (2000) Mammalian neural stem cells. Science. 287(5457):1433-8.
      2. Elkabetz Y, et al. (2008) Human ESC-derived neural rosettes and neural stem cell progression. Cold Spring Harb Symp Quant Biol. 73:377-87.
      3. Goldberg JS, et al. (2009) Diverse roles of the vasculature within the neural stem cell niche. Regen Med. 4(6):879-97.
      4. Conti L, et al. (2010) Neural stem cell systems: physiological players or in vitro entities? Nat Rev Neurosci. 11(3):176-87.
      5. Silver DL, et al. (2010) The exon junction complex component Magoh controls brain size by regulating neural stem cell division. Nat Neurosci. 13(5):551-8.