Anti-Nectin-2 Antibody

Cat: 80327-RP01
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All Nectin-2 Reagents
Anti-Nectin-2 Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-Nectin-2 Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Rat
Specificity
Rat Nectin-2
Immunogen
Recombinant Rat Nectin-2 / PVRL2 protein (Catalog#80327-R08H)
Preparation
Produced in rabbits immunized with purified, recombinant Rat Nectin-2 / PVRL2 (rR Nectin-2 / PVRL2; Catalog#80327-R08H; Q9ESS6; Met1-Gly351). Total IgG was purified by Protein A affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-Nectin-2 Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:1000-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Nectin-2 Background Information

Cluster of Differentiation 112 (CD112), also known as poliovirus receptor related protein 2 (PVRL2 or PRR2), is a single-pass type I transmembrane glycoprotein belonging to the Immunoglobulin superfamily. CD112 protein also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and thus is involved in cell to cell spreading of these viruses. CD112 protein has been identified as the ligand for DNAM-1 (CD226), and the interaction of CD226/CD112 protein can induce NK cell- and CD8+ T cell-mediated cytotoxicity and cytokine secretion. CD112 has been regarded as a critical component in allergic reactions, and accordingly may function as a novel target for anti-allergic therapy.

Full Name
poliovirus receptor-related 2 (herpesvirus entry mediator B)
References
  • Bachelet I, et al. (2006) Mast cell costimulation by CD226/CD112 (DNAM-1/Nectin-2): a novel interface in the allergic process. J Biol Chem. 281(37): 27190-6.
  • Wang L, et al. (2009) Molecular cloning, characterization and three-dimensional modeling of porcine nectin-2/CD112. Vet Immunol Immunopathol. 132(2-4): 257-63.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-Nectin-2 Antibody Rabbit Monoclonal ELISA 80327-R013
    Anti-Nectin-2 Antibody Rabbit Polyclonal ELISA,IHC-P 80327-T24
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    Anti-Nectin-2 Antibody Rabbit Monoclonal WB,ELISA,IP 50318-R110
    Anti-Nectin-2 Antibody (PE) Rabbit Monoclonal FCM 10005-R005-P
    Anti-Nectin-2 Antibody Mouse Monoclonal ELISA 10005-MM01
    Anti-Nectin-2 Antibody Rabbit Polyclonal WB,ELISA,IP 10005-RP04
    Anti-Nectin-2 Antibody Rabbit Monoclonal ELISA,ELISA(Cap),FCM 10005-R005
    Anti-Nectin-2 Antibody Rabbit Monoclonal ELISA 10005-R017
    Anti-Nectin-2 Antibody Rabbit Polyclonal ELISA 10005-RP03
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