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>Human Cell Expressed
>Mouse Neurexophilin-1 / NXPH1 Protein (His Tag)
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Neurexophilin 1 Protein Datasheet
NXPH1 / Neurexophilin-1 Protein Price Inquiry ( Available Sizes )
NXPH1 / Neurexophilin-1 Protein Product Information
|Synonym :||NXPH1, Nph1|
A DNA sequence encoding the mouse NXPH1 (Q61200) (Ala22-Gly271) was expressed with a C-terminal polyhistidine tag.
|Expression Host:||Human Cells|
NXPH1 / Neurexophilin-1 Protein QC Testing
|Purity:||> 85% as determined by SDS-PAGE||SDS-PAGE:
NXPH1 / Neurexophilin-1 protein
|Endotoxin:||< 1.0 EU per μg of the protein as determined by the LAL method|
|Stability:||Samples are stable for up to twelve months from date of receipt at -70℃|
|Predicted N terminal:||Ala 22|
The recombinant mouse NXPH1 comprises 261 amino acids and has a predicted molecular mass of 30.1 kDa. The apparent molecular mass of the protein is approximately 46-48 kDa in SDS-PAGE under reducing conditions due to glycosylation.
|Formulation:||Lyophilized from sterile PBS, pH7.4.
NXPH1 / Neurexophilin-1 Protein Usage Guide
|Storage:||Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.|
|Reconstitution:||A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.|
NXPH1 / Neurexophilin-1 Protein Related Products & Topics
|Molecule||Species||Description //For Detailed Info. and Price------CLICK!||Cat. No|
|Neurexophilin-1/NXPH1||Mouse||NXPH1 / Neurexophilin-1 Protein, Recombinant||50865-M08H|
|Neurexophilin-1/NXPH1||Rat||Neurexophilin-1/NXPH1 Protein, Recombinant||80047-R08H|
NXPH1 / Neurexophilin-1 Protein Description
Neurexophilin-1 ( NXPH1 ) is a member of the neurexophilin family, this secreted protein with a variable N-terminal domain, a highly conserved, N-glycosylated central domain, a short linker region, and a cysteine-rich C-terminal domain. Neurexophilin-1 protein is encoded by the NXPH1 gene, which has highest level in brain. It was discovered as a neuronal glycoprotein that is copurified with neurexin Ialpha during affinity chromatography on immobilized alpha-latrotoxin. Neurexophilins represent a family of extracellular signaling molecules that interact with multiple receptors including all three alpha-neurexins. The mammalian brains contain four genes for neurexophilins the products of which share a common structure composed of five domains. Neurexophilins 1 and 3 but not 4 bind to a single individual LNS domain, the second overall LNS domain in all three alpha-neurexins. Neurexophilin-1 may be proteolytically processed at the boundary between the N-terminal non-conserved and the central conserved domain in neuron-like cells. As a secreted cysteine-rich glycoprotein, Neurexophilin-1 is synthesized in a subclass of neurons, and may be signaling molecules that resemble neuropeptides.
- Petrenko AG. et al., 1996, J Neurosci. 16(14): 4360-9.
- Missler M. et al., 1998, J Biol Chem. 273(52): 34716-23.
- Missler M. et al., 1998, J Neurosci. 18(10): 3630-8.