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NUDT2 Protein, Antibody, ELISA Kit, cDNA Clone

NUDT2 Related Areas

NUDT2 Related Pathways

NUDT2 Related Product

    NUDT2 Summary & Protein Information

    NUDT2 Background

    Gene Summary: This gene encodes a member of the MutT family of nucleotide pyrophosphatases, a subset of the larger NUDIX hydrolase family. The gene product possesses a modification of the MutT sequence motif found in certain nucleotide pyrophosphatases. The enzyme asymmetrically hydrolyzes Ap4A to yield AMP and ATP and is responsible for maintaining the intracellular level of the dinucleotide Ap4A, the function of which has yet to be established. This gene may be a candidate tumor suppressor gene. Alternative splicing has been observed at this locus and four transcript variants, all encoding the same protein, have been identified.
    General information above from NCBI
    Catalytic activity: P(1),P(4)-bis(5'-guanosyl) tetraphosphate + H(2)O = GTP + GMP.
    Cofactor: Divalent ions (By similarity).
    Sequence similarity: Belongs to the Nudix hydrolase family.
    Contains 1 nudix hydrolase domain.C
    General information above from UniProt

    NUDT2 Alternative Name

    Ap4A hydrolase,APAH1,MGC10404,NUDT2, [human]
    2310051L06Rik,AA939917,Ap4A hydrolase,APAH1,Nudt2,RP23-100C7.1, [mouse]

    NUDT2 Related Studies

  • McLennan AG, et al.,1998, Genomics 47(2): 307-9.
  • Aldenhoven,J. et al.,2003, Cytogenet Genome Res.102 (1-4):121-7.
  • Oka,K. et al., 2011, Int J Cancer. 128 (8):1770-82.
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