Text Size:AAA

Rat TrkB / NTRK2 Protein (His Tag)

DatasheetSpecific ReferencesReviewsRelated ProductsProtocols
TrkB/NTRK2Protein Product Information
Synonym:NTRK2, Trkb
Protein Construction:A DNA sequence encoding the rat NTRK2 (Q63604-Isoform T1) (Met1-His429) was expressed with a polyhistidine tag at the C-terminus.
Species:Rat
Expressed Host:Human Cells
Form & Shipping:In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
TrkB/NTRK2Protein QC Testing
Purity:> 95 % as determined by SDS-PAGE
Bio-Activity:Measured by its binding ability in a functional ELISA.
Immobilized rat NTRK2-His at 10 μg/ml (100 μl/well) can bind biotinylated mouse BDNF (cat:50240-MNAS), The EC50 of biotinylated mouse BDNF (cat:50240-MNAS) is 12.2-28.6 ng/ml.
Endotoxin:< 1.0 EU per μg of the protein as determined by the LAL method
Stability:Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N Terminal:Cys 32
Formulation:Lyophilized from sterile PBS, pH 7.4
1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
2. Please contact us for any concerns or special requirements.
Molecule Mass:The recombinant rat NTRK2 comprises 409 amino acids and predicts a molecular mass of 47.1 kDa. The apparent molecular mass of the recombinant protein is approximately 67 kDa in SDS-PAGE under reducing conditions due to glycosylation.
TrkB/NTRK2Protein Usage Guide
Storage:Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution:A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
80243-R08H
Background

TrkB receptor also known as TrkB tyrosine kinase or BDNF/NT-3 growth factors receptor or neurotrophic tyrosine kinase, receptor, type 2 (NTRK2) is a single transmembrane catalytic receptors with intracellular tyrosine kinase activity. TrkB/NTRK2 is a member of the neurotrophic tyrosine receptor kinase (NTRK) family. TrkB tyrosine kinase (TrkB) or NTRK2 is coupled to the Ras, Cdc42/Rac/RhoG, MAPK, PI3-K and PLCgamma signaling pathways. There are four members of the Trk family; TrkA, TrkB and TrkC and a related p75NTR receptor. Each family member binds different neurotrophins with varying affinities. TrkB/NTRK has highest affinity for brain-derived neurotrophic factor (BDNF) and is involved in neuronal plasticity, longterm potentiation and apoptosis of CNS neurons. Other neurotrophins include nerve growth factor(NGF), neurotrophin-3 and neurotrophin-4. TrkB/NTRK is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in TrkB/NTRK have been associated with obesity and mood disorders.

References
  • Klein R, et al. (1990) The trkB tyrosine protein kinase gene codes for a second neurogenic receptor that lacks the catalytic kinase domain. Cell. 61 (4): 647-56.
  • Rose CR, et al. (2003) Truncated TrkB-T1 mediates neurotrophin-evoked calcium signalling in glia cells. Nature. 426 (6962): 74-8.
  • Yamada K, et al. (2004) Brain-derived neurotrophic factor/TrkB signaling in memory processes. J Pharmacol Sci. 91 (4): 267-70.
  • Rat TrkB / NTRK2 Protein (His Tag) on other vectors Rat TrkB / NTRK2 Protein (His Tag) on other vectors
    Receptor Tyrosine Kinase (RTK) Related Products
    Product nameProduct name
    Mouse EphB2 / Hek5 Protein (His Tag)Human CD136 / MST1R Protein (His Tag)Human CSF1R / MCSF Receptor / CD115 Protein (His & Fc Tag)Human CSF1R / MCSF Receptor / CD115 Protein (His Tag)Human Tie1 Protein (His Tag)Human PDGFRB / CD140b Protein (His & Fc Tag)Human CSF1R / MCSF Receptor / CD115 Protein (His & GST Tag)Human CSF1R / MCSF Receptor / CD115 Protein (aa 543-922, His & GST Tag)Human CSF1R / MCSF Receptor / CD115 ProteinHuman CD140b / PDGFRB Protein (His Tag)Mouse EphA4 / HEK8 Protein (Fc Tag)Mouse EphA4 / HEK8 Protein (His Tag)Mouse EphB3 / HEK2 Protein (His Tag)Mouse EphB4 / HTK Protein (Fc Tag)Mouse EphB4 / HTK Protein (His Tag)Human IGF1R / CD221 Protein (His Tag)Human PDGFRB / PDGFR-1 / CD140b ProteinMouse VEGFR3 / FLT-4 Protein (Fc Tag)Mouse VEGFR3 / FLT-4 Protein (His Tag)Mouse EGFR / HER1 / ErbB1 Protein (His Tag)Cynomolgus / Rhesus c-MET / HGFR Protein (Fc Tag)Mouse EphA2 Protein (His Tag)Mouse EphA7 / EHK-3 Protein (His Tag)Cynomolgus / Rhesus c-MET / HGFR Protein (His Tag)Canine TrkA / NTRK1 Protein (Fc Tag)Canine TrkA / NTRK1 Protein (His Tag)Cynomolgus HER2 / ErbB2 Protein (ECD, Fc Tag)Rat c-MET / HGFR Protein (Fc Tag)Human / Rhesus HER4 / ErbB4 Protein (His Tag)Mouse CSF1R / MCSF Receptor / CD115 Protein (His & Fc Tag)Mouse CSF1R / MCSF Receptor / CD115 Protein (His Tag)Human FGFR1 / CD331 Protein (His & Fc Tag)Human FGFR4 / FGF Receptor 4 Protein (Fc Tag)Human FGFR4 / FGF Receptor 4 Protein (His & Fc Tag)Human FGFR4 / FGF Receptor 4 Protein (His Tag)Mouse EphB1 / EPHT2 Protein (His Tag)Human PDGFRa / CD140a Protein (Fc Tag)Human PDGFRa / CD140a Protein (His Tag)Human PDGFRa / CD140a Protein (His & GST Tag)Human PDGFRa / CD140a ProteinMouse FGFR3 / CD333 Protein (His & Fc Tag)Mouse FGFR3 / CD333 Protein (His Tag)Human EphA7 / EHK3 Protein (His Tag)Rat Tie2 / TEK Protein (Fc Tag)Rat HER2 / ErbB2 Protein (Fc Tag)Rat HER2 / ErbB2 Protein (His Tag)Human HER4 / ErbB4 Protein (His & Fc Tag)Human EphA7 / EHK3 Protein (His & GST Tag)Rat HER2 / ErbB2 ProteinRat FGFR4 / FGF Receptor 4 Protein (Fc Tag)Human EphB6 / EphB6 Protein (Fc Tag)Rat FGFR4 / FGF Receptor 4 Protein (His Tag)Human EphB6 / EphB6 Protein (His Tag)Human EphB6 / EphB6 ProteinRat VEGFR1 / FLT-1 Protein (His Tag)Mouse c-MET / HGFR Protein (Fc Tag)Rat HER3 / ErbB3 Protein (Fc Tag)Rat HER3 / ErbB3 Protein (His Tag)Rat VEGFR2 / Flk-1 / CD309 / KDR Protein (Fc Tag)Rat VEGFR2 / Flk-1 / CD309 / KDR Protein (His Tag)Rat EphA4 Protein (Fc Tag) Rat EphA4 Protein (His Tag)Rat HER4 / ErbB4 Protein (Fc Tag)Rat HER4 / ErbB4 Protein (His Tag)Mouse c-MET / HGFR Protein (His Tag)Mouse EphA6 / EHK-2 Protein (Fc Tag)Mouse EphA6 / EHK-2 Protein (His Tag)Human HER3 / ErbB3 Protein (Fc Tag)Human HER3 / ErbB3 Protein (Fc Tag)Human HER3 / ErbB3 Protein (His Tag)Human HER3 / ErbB3 Protein (aa 730-1065, His & GST Tag)Rat TrkB / NTRK2 Protein (Fc Tag)Rat TrkB / NTRK2 Protein (His Tag)Human DDR2 Kinase / CD167b Protein (Fc Tag)Human DDR2 Kinase / CD167b Protein (His Tag)Human DDR2 Kinase / CD167b Protein (aa 422-855, His & GST Tag)Canine TrkB / NTRK2 Protein (His Tag)Cynomolgus FGFR3 Protein (Fc Tag)Human FGFR1 / CD331 Protein (His Tag)Human FGFR1 / CD331 Protein (His & GST Tag)Cynomolgus / Rhesus c-MET / HGFR ProteinRat KIT / c-KIT Protein (Fc Tag)Rat KIT / c-KIT Protein (His Tag)Cynomolgus HER2 / ErbB2 Protein (His Tag)Human VEGFR1 / FLT-1 Protein (Fc Tag)Rat DDR2 Kinase / CD167b Protein (Fc Tag)Rat DDR2 Kinase / CD167b Protein (His Tag)Rat PDGFRB / PDGFR-1 Protein (Fc Tag)Rat PDGFRB / PDGFR-1 Protein (His Tag)Human VEGFR1 / FLT-1 Protein (His Tag)Mouse Axl Kinase Protein (His & Fc Tag)Mouse Axl Kinase Protein (His Tag)Human EphB4 / HTK Protein (Fc Tag)Human EphB4 / HTK Protein (His Tag)Human EphB4 / HTK Protein (aa 563-987, His & GST Tag)Human EphB4 / HTK ProteinMouse TrkB / NTRK2 Protein (His Tag)Rat TrkA / NTRK1 Protein (Fc Tag)Rat TrkA / NTRK1 Protein (His Tag)Rat PDGFRa / CD140a Protein (Fc Tag)Rat PDGFRa / CD140a Protein (His Tag)Mouse Tie2 / CD202b / TEK Protein (ECD, Fc Tag)Rat DDR1 Kinase / MCK10 / CD167 Protein (Fc Tag) Mouse FGFR2 / CD332 Protein (Fc Tag)Rat DDR1 Kinase / MCK10 / CD167 Protein (His Tag)Rat CSF1R / MCSF Receptor / CD115 Protein (Fc Tag)Rat CSF1R / MCSF Receptor / CD115 Protein (His Tag)Mouse FGFR2 / CD332 Protein (His Tag)Rat EGFR / HER1 / ErbB1 Protein (His Tag)Mouse EphB2 / Hek5 Protein (Fc Tag)Mouse EphB6 Protein (His Tag)Human c-MET / HGFR Protein (His & Fc Tag)Human c-MET / HGFR Protein (His Tag)Human c-MET / HGFR Protein (aa 956-1390, His & GST Tag)Rhesus HER2 / ErbB2 Protein (Fc Tag)Rhesus HER2 / ErbB2 Protein (His Tag)Human Tie2 / CD202b / TEK Protein (His & GST Tag)Cynomolgus EphA4 Protein (Fc Tag)Mouse FGFRL1 / FGFR5 Protein (His Tag)Mouse FGFR1 / CD331 Protein (Fc Tag)Mouse Tie2 / TEK Protein (aa 770-1122, His & GST Tag)Human TrkA / NTRK1 Protein (His & Fc Tag)Human TrkA / NTRK1 Protein (aa 285-413, His Tag)Human TrkA / NTRK1 Protein (aa 194-413, His Tag)Cynomolgus EphA4 Protein (His Tag)Cynomolgus EphB1 / EPHT2 Protein (Fc Tag)Cynomolgus EphB1 / EPHT2 Protein (His Tag)Rhesus HER3 / ErbB3 Protein (Fc Tag)Rhesus HER3 / ErbB3 Protein (His Tag)Cynomolgus EphB6 / EphB6 Protein (Fc Tag)Mouse HER2 / ErbB2 Protein (Fc Tag)Mouse HER2 / ErbB2 / CD340 Protein (His Tag)Human TrkA / NTRK1 Protein (His Tag)Human Axl Kinase Protein (His Tag)Mouse FGFR1 / CD331 Protein (His Tag)Cynomolgus FGFR1 / CD331 Protein (Fc Tag)Cynomolgus FGFR1 / CD331 Protein (His Tag)Canine TrkB / NTRK2 Protein (Fc Tag)Human Insulin Receptor / INSR / CD220 Protein (long isoform, His Tag)Human Insulin Receptor / INSR / CD220 Protein (His & GST Tag)Human MERTK / Mer Protein (His & Fc Tag)Human MERTK / Mer Protein GST TagHuman MERTK / Mer(aa 578-872) ProteinHuman Tie2 / CD202b Protein (His & Fc Tag)Human Tie2 / CD202b / TEK Protein (His Tag)Mouse FGFR4 / CD334 Protein (His & Fc Tag)Mouse FGFR4 / CD334 Protein (His Tag)Human EGFR / HER1 / ErbB1 Protein (His Tag)Human MUSK Kinase Protein (aa 433-783, His & GST Tag)Cynomolgus FGFR4 / FGF Receptor 4 Protein (Fc Tag)Cynomolgus FGFR4 / FGF Receptor 4 Protein (His Tag)Rhesus HER3 / ErbB3 ProteinHuman Insulin Receptor / INSR / CD220 Protein (short isoform, His Tag)Mouse DDR1 Kinase / MCK10 / CD167 Protein (His & GST Tag)Human EphB2 / Hek5 Protein (aa 570-987, His & GST Tag)Cynomolgus / Rhesus FGFR3 / CD333 Protein (His Tag)Human DDR1 Kinase / MCK10 / CD167 Protein (His Tag)Human DDR1 Kinase / MCK10 / CD167 Protein (aa 444-913, His & GST Tag)Mouse EphA1 / EPH receptor A1 Protein (His Tag)Mouse DDR1 Kinase / MCK10 / CD167 Protein (Fc Tag)Mouse DDR1 Kinase / MCK10 / CD167 Protein (His Tag)Canine HER2 / ErbB2 Protein (His Tag)Canine EGFR / HER1 / ErbB1 Protein (His Tag)Cynomolgus PDGFRB / PDGFR-1 Protein (His Tag)Cynomolgus DDR2 Kinase / CD167b Protein (Fc Tag)Cynomolgus DDR2 Kinase / CD167b Protein (His Tag)Human EphB2 Protein (His & Fc Tag)Human EphB2 Protein (His Tag)Human EphB2 / Hek5 ProteinHuman KIT / c-KIT / CD117 Protein (aa 540-972, His & GST Tag)Cynomolgus Tie2 / TEK Protein (Fc Tag)Human EphB1 / EPHT2 Protein (aa 565-984, His & GST Tag)Human EphB3 / HEK2 Protein (aa 585-998, His & GST Tag)Human EphA2 Protein (aa 585-976, His & GST Tag)Human EGFR / HER1 / ErbB1 Protein (His Tag)Mouse TrkC / NTRK3 Protein (His Tag)Mouse VEGFR2 / Flk-1 / CD309 / KDR Protein (Fc Tag)Mouse VEGFR2 / Flk-1 / CD309 / KDR Protein (His Tag)Mouse HER3 / ErbB3 Protein (His Tag)Human VEGFR3 / FLT4 Protein (Fc Tag)Human VEGFR3 / FLT4 Protein (His Tag)Human EGFR / HER1 / ErbB1 Protein (Fc Tag)Mouse EphB1 / EPHT2 Protein (His & GST Tag)Human / Rhesus HER4 / ErbB4 Protein (Fc Tag)Human / Rhesus HER4 / ErbB4 Protein (His Tag)Human HER2 / ErbB2 Protein (Fc Tag)Human HER2 / ErbB2 Protein (His Tag)Human HER2 / ErbB2 / CD340 (676-1255) Protein (His & GST Tag)Mouse HER4 / ErbB4 Protein (His Tag)Human EphA2 Protein (His Tag)Human VEGFR2 / Flk-1 / CD309 / KDR Protein (Fc Tag)Human VEGFR2 / Flk-1 / CD309 / KDR Protein (His Tag)Human VEGFR2 / Flk-1 / CD309 / KDR Protein (His & GST Tag)Mouse Tie2 / TEK Protein (His Tag)Mouse EGFR / HER1 / ErbB1 Protein (Fc Tag)Human FGFR2 Protein (His & Fc Tag)Human FGFR2 / CD332 Protein (His Tag)Human FGFR2 / CD332 Protein (aa 400-821, His & GST Tag)Mouse TrkA / NTRK1 Protein (Fc Tag)Mouse TrkA / NTRK1 Protein (His Tag)Human KIT / c-KIT / CD117 Protein (aa 50-190, His Tag)Human TrkB / NTRK2 Protein (His & Fc Tag)Human TrkB / NTRK2 Protein (His Tag)Human TrkC / NTRK3 Protein (His & Fc Tag)Human TrkC / NTRK3 Protein (His Tag)Human EphB1 / EPHT2 Protein (His Tag)Rat EphA7 / EHK3 Protein (His Tag)Human EGFR / HER1 / ErbB1 (aa 668-1210) Protein (His & GST Tag)Human KIT / c-KIT / CD117 Protein (Fc Tag)Canine c-MET / HGFR Protein (His Tag)Human c-KIT / CD117 Protein (His Tag)Human RET Kinase Protein (His Tag)Human RET Kinase Protein (aa 658-1114, His & GST Tag)Human EphA4 Protein (His & Fc Tag)Human EphA4 Protein (His Tag)Human EphA4 / HEK8 Protein (aa 570-986, His & GST Tag)Mouse MERTK / Mer Protein (Fc Tag)Mouse MERTK / Mer Protein (His & GST Tag)Mouse c-kit / CD117 Protein (Fc Tag)Mouse c-kit / CD117 Protein (His Tag)Human VEGFR1 / FLT-1 Protein (His Tag)Mouse DDR2 Kinase / CD167b Protein (His Tag)
    Catalog:80243-R08H-20
    List Price: $138.00  (Save $0.00)
    Price:$138.00      [How to order]
    Availabilityon Sale
    Images
    • Rat TrkB / NTRK2 Protein (His Tag) SDS-PAGE
    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"