NTPDase 2 (ENTPD2)

NTPDase 2, also known as ENTPD2, belongs to the ecto-nucleoside triphosphate diphosphohydrolase family (E-NTPDase). Members of E-NTPDase family are nucleotidases able to hydrolyze 5′-nucleoside tri- and/or diphosphates; the main role of these enzymes is the termination of purinergic signaling. NTPDases are ubiquitous and were previously shown in other parasites including the trypanosomatides of genus Leishmania and in T. brucei. NTPase activity would act as a timer and is crucial to T. gondii infection. In L. pneumophila it was demonstrated that an E-NTPDase, similar to CD39, is essential for intracellular bacterial multiplication. NTPDase 2 is an integral membrane protein. In the nervous system, it could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Alternative splicing of NTPDase 2 gene results in multiple transcript variants.

NTPDase 2 (ENTPD2) Related Areas

Enzyme >>Other>> NTPDase 2 / ENTPD2

NTPDase 2 (ENTPD2) Alternative Names

RP11-229P13.11-001, CD39L1, NTPDase-2, CD39 antigen-like 1, NTPDase 2, ecto-ATP diphosphohydrolase 2, ecto-ATPDase 2, ecto-ATPase 2 [Homo sapiens]

RP23-47P18.5, Cd39l1, NTPDase2, CD39 antigen-like 1, NTPDase 2, ecto-ATP diphosphohydrolase 2, ecto-ATPDase 2, ecto-ATPase 2 [Mus musculus]

Summaries for NTPDase 2 (ENTPD2)

Entrez Gene summary for ENTPD2:

The protein encoded by this ENTPD2 gene is the type 2 enzyme of the ecto-nucleoside triphosphate diphosphohydrolase family (E-NTPDase). E-NTPDases are a family of ecto-nucleosidases that hydrolyze 5'-triphosphates. This ecto-ATPase is an integral membrane protein. Alternative splicing of this ENTPD2 gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]

Wikipedia summary for NTPDase 2:

Ectonucleoside triphosphate diphosphohydrolase 2 is an enzyme that in humans is encoded by the ENTPD2 gene.
It has been shown, by scientists from the University of Warwick, that E-NTPDase2 stimulates the growth of the eye: by testing the enzyme on tadpoles, the tadpoles were found to develope extra eyes on their body.

Human NTPDase 2 (ENTPD2) Protein General Information

 

• Protein names: Ectonucleoside triphosphate diphosphohydrolase 2, Short name=NTPDase 2
• Sequence length: 495 AA.
• Sequence similarities: Belongs to the GDA1/CD39 NTPase family.
• Cofactor: Calcium. Magnesium.
• Subcellular location: Membrane; Multi-pass membrane protein
• Tissue specificity: Brain, placenta, skeletal muscle, kidney, pancreas, heart, ovary, testis, colon, small intestine, prostate and pancreas. No expression in adult thymus, spleen, lung, liver and peripheral blood leukocytes.

General information above from UniProt

Function for NTPDase 2 (ENTPD2) Protein

UniProtKB:

In the nervous system, NTPDase 2 could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. NTPDase 2 hydrolyzes ADP only to a marginal extent. The order of activity with different substrates is ATP > GTP > CTP = ITP > UTP >> ADP = UDP.

Genatlas:

• NTPDase 2 is ecto-nucleosidases that hydrolyze 5'-triphosphates
• NTPDase 2 is expressed at a much lower level than ENTPD5, but was also elevated in PTEN null cells

Homology for human NTPDase 2 (ENTPD2)

• ortholog to chicken muscle ecto ATPase 2
• homolog to lymphoid cell activation antigen CD39