C1D Protein (GST Tag)

C1D nuclear receptor corepressor Protein Datasheet

C1D Protein Product Information

• Synonym: LRP1, MGC12261, MGC14659, SUN-CoR, SUNCOR, hC1D
• Protein Construction: A DNA sequence encoding the human C1D (Q13901) (Met 1-Ser 141) was fused with the GST tag at the N-terminus.
• Source: Human
• Expression Host: E.coli

C1D Protein QC Testing

• Purity: > 80 % as determined by SDS-PAGE
• Endotoxin: Please contact us for more information.
• Stability: Samples are stable for up to twelve months from date of receipt at -70℃
• Predicted N terminal: Met
• Molecular Mass: The recombinant human C1D/GST chimera consists of 375 amino acids and has a predicted molecular mass of 43.2 kDa. It migrates as an approximately 43 KDa band in SDS-PAGE under reducing conditions.
• Formulation: Lyophilized from sterile PBS, pH 7.5.
  1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
  2. Please contact us for any concerns or special requirements.
• SDS-PAGE: C1D protein

C1D Protein Usage Guide

• Storage: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

C1D Protein Description

C1D nuclear receptor corepressor is a member of the C1D family. As a DNA binding and apoptosis-inducing protein, C1D nuclear receptor corepressor interacts with TSNAX and DNA-PKcs. It is thought that C1D nuclear receptor corepressor regulates TRAX/Translin complex formation. C1D nuclear receptor corepressor acts as a corepressor for the thyroid hormone receptor. It is expressed in kidney, heart, brain, spleen, lung, testis, liver and small intestine. It plays a role in the recruitment of the RNA exosome complex to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA; this function may include MPHOSPH6. It potentiates transcriptional repression by NR1D1 and THRB. C1D nuclear receptor corepressor can activate PRKDC not only in the presence of linear DNA but also in the presence of supercoiled DNA. It also can induce apoptosis in a p53/TP53 dependent manner.

References

1. Schilders G. et al., 2007, Arthritis Rheum. 56 (7): 2449-54.
2. Schilders G. et al., 2007, Nucleic acids Res. 35 (8): 2564-72.
3. Erdemir T. et al., 2002, J Cell Sci. 115 (1): 207-16.