Anti-NRXN3 Antibody

Cat: 11843-RP02
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Anti-NRXN3 Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-NRXN3 Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human NRXN3
Immunogen
Recombinant Human NRXN3 / Neurexin 3 protein (Catalog#11843-H08H)
Preparation
Produced in rabbits immunized with purified, recombinant Human NRXN3 / Neurexin 3 (rh NRXN3 / Neurexin 3; Catalog#11843-H08H; NP_620426.2; Met 1-Thr 357). NRXN3 / Neurexin 3Human NRXN3 / Neurexin 3 affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-NRXN3 Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:5000-1:10000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-NRXN3 Antibody Alternative Names
Anti-C14orf60 Antibody
NRXN3 Background Information

Neurexin-3-beta, also known as Neurexin III-beta and NRXN3, is a single-pass type I  membrane protein which belongs to the neurexin family. It contains one laminin G-like domain. It is a neuronal cell surface protein that may be involved in cell recognition and cell adhesion. Neurexins are a family of proteins that function in the vertebrate nervous system as cell adhesion molecules and receptors. They are encoded by several unlinked genes of which two, NRXN1 and NRXN3, are among the largest known human genes. Three of the genes ( NRXN1, NRXN2, NRXN3 ) utilize two alternate promoters and include numerous alternatively spliced exons to generate thousands of distinct mRNA transcripts and protein isoforms. The majority of transcripts are produced from the upstream promoter and encode alpha-neurexin isoforms; a much smaller number of transcripts are produced from the downstream promoter and encode beta-neurexin isoforms. The alpha-neurexins contain EGF-like sequences and laminin G domains, and have been shown to interact with neurexophilins. The beta-neurexins lack EGF-like sequences and contain fewer laminin G domains than alpha-neurexins. NRXN3 have been linked to genetic predisposition towards a number of conditions such as alcohol or drug addiction, or obesity.

Full Name
neurexin 3
References
  • Occhi G. et al., 2002, Biochem. Biophys. Res. Commun. 298:151-5.
  • Rowen L, et al., 2002, Genomics. 79 (4): 587-97.
  • Olsen J.V. et al., 2006, Cell 127:635-48.
  • Hishimoto A, et al., 2007, Human Molecular Genetics.16 (23): 2880-91.
  • Oppermann F.S. et al., 2009, Mol. Cell. Proteomics 8:1751-64. 
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-NRXN3 Antibody Rabbit Polyclonal ELISA 11843-RP01
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