NRG1 Protein Price Inquiry ( Available Sizes )
NRG1 Protein Product Information
||NRG1, GGF, HGL, HRGA, NDF, SMDF
||A DNA sequence encoding the human NRG1(Q02297--isoform6) (Ser2-Lys246) was expressed, fused with the Fc region of mouse IgG1 at the N-terminus.
NRG1 Protein QC Testing
||> 88 % as determined by SDS-PAGE
||< 1.0 EU per μg of the protein as determined by the LAL method
||Samples are stable for up to twelve months from date of receipt at -70℃
|Predicted N terminal:
The recombinant human NRG1/mFc comprises 481 amino acids and has a predicted molecular mass of 53.4 kDa. The apparent molecular mass of the monomer is approximately 67 kDa in SDS-PAGE under reducing conditions due to glycosylation.
||Lyophilized from sterile PBS,pH7.4.
- Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
- Please contact us for any concerns or special requirements.
NRG1 Protein Usage Guide
||Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
||A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
NRG1 Protein Related Products & Topics
NRG1 Protein Description
Neuregulin 1 or NRG1 is one of four proteins in the neuregulin family that act on the EGFR family of receptors. This growth factor was originally identified as a 44-kD glycoprotein that interacts with the NEU / ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. NRG1 is a trophic factor that has been implicated in neural development, neurotransmission, and synaptic plasticity. NRG1 has multiple isoforms that are generated by usage of different promoters and alternative splicing of a single gene. Neuregulin 1 (NRG1) is essential for the development and function of multiple organ systems, and its dysregulation has been linked to diseases such as cancer and schizophrenia. NRG1 is a schizophrenia candidate gene and plays an important role in brain development and neural function. Schizophrenia is a complex disorder, with etiology likely due to epistasis.
- Nicodemus KK. et al., 2010, Arch Gen Psychiatry. 67 (10): 991-1001.
- Tan W. et al., 2007, J Biol Chem. 282 (33): 24343-51.
- Holmes WE. et al., 1992, Science. 256 (5060): 1205-10.