All Nucleophosmin reagents are produced in house and quality controlled, including 2 Nucleophosmin Antibody, 42 Nucleophosmin Gene, 2 Nucleophosmin Protein, 2 Nucleophosmin qPCR. All Nucleophosmin reagents are ready to use.
Recombinant Nucleophosmin proteins are expressed by E. coli with fusion tags as N-His.
Nucleophosminantibodies are validated with different applications, which are WB, ELISA.
NucleophosmincDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each Nucleophosmin of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
Nucleophosmin 1 (NPM1), also known as nucleolar phosphoprotein B23 or numatrin, is a member of the nucleoplasmin family. Nucleophosmin (NPM) is a nucleolar phosphoprotein that plays multiple roles in ribosome assembly and transport, cytoplasmic-nuclear trafficking, centrosome duplication and regulation of p53. The NPM1 gene is frequently involved in chromosomal translocation, mutation and deletion. Mutations of the NPM1 gene leading to the expression of a cytoplasmic mutant protein, NPMc+, are the most frequent genetic abnormalities found in acute myeloid leukemias. Acute myeloid leukemias (AML) with mutated NPM1 have distinct characteristics, including a significant association with a normal karyotype, involvement of different hematopoietic lineages, a specific gene-expression profile and clinically, a better response to induction therapy and a favorable prognosis. In addition, NPM1 is a crucial gene to consider in the context of the genetics and biology of cancer. NPM1 is frequently overexpressed, mutated, rearranged and deleted in human cancer. Traditionally regarded as a tumour marker and a putative proto-oncogene, it has now also been attributed with tumour-suppressor functions.