Anti-NME1 Antibody (FITC)

Cat: 11615-MM01-F
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Anti-NME1 Antibody (FITC) (Mouse Monoclonal antibody) General Information
Product name
Anti-NME1 Antibody (FITC)
Validated applications
FCM
Species reactivity
Reacts with: Human
Specificity
Human NME1
Immunogen
Recombinant Human NME1 / NDKA protein (Catalog#11615-H07E)
Preparation
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human NME1 / NDKA (rh NME1 / NDKA; Catalog#11615-H07E; NP_000260.1; Ala 2-Glu 152) and conjugated with FITC under optimum conditions, the unreacted FITC was removed.
Source
Monoclonal Mouse IgG1 Clone #01
Purification
Protein A
Formulation
Aqueous solution containing 0.5% BSA and 0.09% sodium azide
Conjugate
FITC
Concentration
10 μl/Test, 0.1 mg/ml
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze ! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.
Anti-NME1 Antibody (FITC) (Mouse Monoclonal antibody) Validated Applications

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-NME1 Antibody (FITC) (Mouse Monoclonal antibody) Images
Human NME1/NDKA Flow Cytometry (FC) 4835
Flow cytometric analysis of Human NME1 expression in HeLa cells. The cells were treated according to manufacturer’s manual (BD Pharmingen™ Cat. No. 554714), and then stained with FITC Mouse anti-NME1 (11615-MM01-F). The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells.
Anti-NME1 Antibody (FITC) Alternative Names
Anti-AWD Antibody;Anti-GAAD Antibody;Anti-NB Antibody;Anti-NBS Antibody;Anti-NDKA Antibody;Anti-NDPK-A Antibody;Anti-NDPKA Antibody;Anti-NM23 Antibody;Anti-NM23-H1 Antibody
NME1 Background Information

NME1, also known as Nucleoside Diphosphate Kinase A (NDK-A), or NM23-H1, belongs to the NDK family. NM23-H1 is known to have a metastasis suppressive activity in many tumor cells. Recent studies have shown that the interacting proteins with NM23-H1 which mediate the cell proliferation, may act as modulators of the metastasis suppressor activity. The interacting proteins with NM23-H1 can be classified into 3 groups. The first group of proteins can be classified as upstream kinases of NM23-H1 such as CKI and Aurora-A/STK15. The second group of proteins acts as downstream effectors for the regulation of specific gene transcriptions, GTP-binding protein functions, and signal transduction in Erk signal cascade. The third group of proteins can be classified as bi-directionally influencing binding partners of NM23-H1. As a result, the interactions with NM23-H1 and binding partners have implications in the biochemical characterization involved in metastasis and tumorigenesis. NDKA is increased in human postmortem cerebrospinal fluid (CSF), a model of global brain insult, suggesting that measurement in CSF and, more importantly, in plasma may be useful as a biomarker of stroke. Additionally, NM23-H1 significantly reduces metastasis without effects on primary tumor size and was the first discovered metastasis suppressor gene.

Full Name
NME/NM23 nucleoside diphosphate kinase 1
References
  • Allard L, et al. (2005) PARK7 and nucleoside diphosphate kinase A as plasma markers for the early diagnosis of stroke. Clin Chem. 51(11): 2043-51.
  • Steeg PS, et al. (2008) Clinical-translational approaches to the Nm23-H1 metastasis suppressor. Clin Cancer Res. 14(16): 5006-12.
  • Kim HD, et al. (2009) Regulators affecting the metastasis suppressor activity of Nm23-H1. Mol Cell Biochem. 329(1-2): 167-73.
  • Product Description Host Clonality Application Catalog# (PDF)
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    Anti-NME1 Antibody Mouse Monoclonal FCM,ICC/IF,IF 11615-MM01
    Anti-NME1 Antibody Rabbit Monoclonal ELISA 11615-R001
    Anti-NME1 Antibody (PE) Mouse Monoclonal FCM 11615-MM01-P
    Anti-NME1 Antibody Rabbit Monoclonal IHC-P 11615-R084
    Anti-NME1 Antibody Rabbit Polyclonal ELISA 11615-RP01
    Anti-NME1 Antibody Rabbit Polyclonal WB,ELISA,IP 11615-RP02
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