NKR-P1A / Klrb1a Protein

Killer cell lectin-like receptor subfamily B member 1A

NKR-P1A / Klrb1a Products

NKR-P1A / Klrb1a Protein, Recombinant

Molecule	Species	Description	Cat. No
NKR-P1A/Klrb1a	Mouse	NKR-P1A/Klrb1a Protein, Recombinant	50806-M07H

NKR-P1A / Klrb1a cDNA Clone

Molecule	Species	Description	Cat. No
NKR-P1A/Klrb1a	Mouse	Mouse NKR-P1A/Klrb1a cDNA Clone / ORF Clone	MG50806-G

NKR-P1A / Klrb1a Alternative Names

NKR-P1A / Klrb1a, Ly55a, NKR-P1.7, NKR-P1A, NKRP12, Nkrp1-a, Nkrp1a, ly-55A [Mus musculus]

NKR-P1A / Klrb1a Background

Klrb1a (killer cell lectin-like receptor subfamily B member 1A), also known as NKR-P1A (Natural killer cell surface protein P1A), is a homodimeric type II transmembrane protein of the C-type lectin family found on natural killer (NK) cells and NK-like T cells and is an activator of cytotoxicity. The NKR-P1 receptors are a family of C-type lectin-like molecules that were first described in rodents. Initially thought of as markers for NK cells, expression of these molecules has now been documented in other cell types, including subsets of T cells as well as on granulocytes and spleen dendritic cells. In mice, six NKR-P1 genes have been identified, whereas in humans there appears to be only one gene, CD161 (NKR-P1A), expressed on most NK cells and subsets of thymocytes and fetal liver T cells. NKR-P1A protein has been implicated in the triggering of NK-mediated natural killing contributing to target cell recognition by NK cells.

NKR-P1A / Klrb1a Related Studies

1. Plougastel B, et al. (2001) Analysis of a 1-Mb BAC contig overlapping the mouse Nkrp1 cluster of genes: cloning of three new Nkrp1 members, Nkrp1d, Nkrp1e, and Nkrp1f. Immunogenetics 53: 592-598.
2. Kogelberg H, et al. (2000) Expression in Escherichia coli, folding in vitro, and characterization of the carbohydrate recognition domain of the natural killer cell receptor NKR-P1A. Protein Expr Purif. 20(1): 10-20.
3. Grazia Cifone M, et al. (1997) NKR-P1A stimulation of arachidonate-generating enzymes in rat NK cells is associated with granule release and cytotoxic activity. J Immunol. 159(1): 309-17.
4. Josien R, et al. (1997) Rat spleen dendritic cells express natural killer cell receptor protein 1 (NKR-P1) and have cytotoxic activity to select targets via a Ca2+-dependent mechanism. J Exp Med. 186: 467-472.
5. Ryan JC, et al. (1995) NKR-P1A is a target-specific receptor that activates natural killer cell cytotoxicity. J Exp Med. 181(5): 1911-5.
6. Lanier L L, et al. (1994) Human NKR-P1A: a disulfide-linked homodimer of the C-type lectin superfamily expressed by a subset of NK and T lymphocytes. J Immunol. 153: 2417-2428.
7. Chambers W, et al. (1989) Monoclonal antibody to a triggering structure expressed on rat natural killer cells and adherent lymphokine-activated killer cells. J Exp Med. 169: 1373-1389.