NKG2 / NKG2A Protein

Killer cell lectin-like receptor subfamily C, member 1

NKG2 / NKG2A Products

NKG2 / NKG2A Protein, Recombinant

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat No
NKG2 / NKG2A	Human	NKG2A / CD159A / KLRC1 Protein, R ecombinant	13905-H07H

NKG2 / NKG2A cDNA Clone

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat No
NKG2 / NKG2A	Mouse	Mouse KLRC1 Gene cDNA Clone / ORF Clone	MG50834-G
NKG2 / NKG2A	Rat	Rat KLRC1 Gene cDNA Clone / ORF Clone	RG80370-G
NKG2 / NKG2A	Cynomolgus	Cynomolgus monkey KLRC1 Gene cDNA Clone / ORF Clone	CG90214-G

NKG2 / NKG2A Related Areas

Immunology>>Innate Immunity>>Natural Killer Cell (NK Cell)>> NKG2 / NKG2A

NKG2 / NKG2A Alternative Names

CD159A, MGC13374, MGC59791, NKG2, NKG2A, C-lectin type II protein, CD159 antigen-like family member A, NK cell receptor A, NKG2-1/B activating NK receptor, NKG2-A/B type II integral membrane protein, NKG2-A/B-activating NK receptor, NKG2-A/NKG2-B type II integral membrane protein, natural killer cell lectin, natural killer group protein 2 [Homo sapiens]

CD159a, NKG2A, NKG2B, NKG2-A/NKG2-B type II integral membrane protein [Mus musculus]

NKG2 / NKG2A Background

NKG2, also known as NKG2A(CD159A), is a member of the killer cell lectin-like receptor family. This family is a group of transmembrane proteins preferentially expressed in NK cells. Members of this fmaily are characterized by the type II membrane orientation and the presence of a C-type lectin domain. NKG2 contains 1 C-type lectin domain and forms a complex with another family member, KLRD1/CD94. It is expressed only in NK-cells, but not in T-cells or B-cells. It has been shown that NKG2 represents a family of related cDNA clones, designated NKG2A, NKG2B, NKG2C, and NKG2D, which encode type 2 integral membrane proteins (extracellular C-terminus) containing a C-type lectin domain. Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NKG2 functions as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells.

NKG2 / NKG2A Related Studies

1. Angelini DF, et al. (2011) NKG2A inhibits NKG2C effector functions of γδ T cells: implications in health and disease. J Leukoc Biol. 89(1):75-84.
2. Ge SJ, et al. (2011) Expression of NKG2D and NKG2A with their ligands MHC-I A/B and HLA-E in acute leukemia patients and its significance. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 19(2):312-6.
3. Ablamunits V, et al. (2011) NKG2A is a marker for acquisition of regulatory function by human CD8+ T cells activated with anti-CD3 antibody. Eur J Immunol. 41(7):1832-42.