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Human β-NGF / Beta-NGF Protein
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Human β-NGF / Beta-NGF Protein PDF Download

Catalog   Size (Price) Quantity In Stock Operation
11050-HNAC  


YES   
 

Protein Production & Purification Service | Recombinant Cytokines & Growth Factors

Nerve Growth Factor Protein ( β-NGF / Beta-NGF ) Datasheet

 

β-NGF / Beta-NGF Protein Price Inquiry ( Available Sizes )

β-NGF / Beta-NGF Protein Product Information

Synonym: NGF ,  Beta-NGF  ,   HSAN5  ,   MGC161426  ,   MGC161428  ,   NGFB
Protein Construction:

A DNA sequence encoding the mature form of human β-NGF ( NP_002497.2 )  ( Ser 122- Arg 239 ) was expressed

Source: Human
Expression Host: CHO Stable Cells

β-NGF / Beta-NGF Protein QC Testing

Purity: > 95 % as determined by SDS-PAGE SDS-PAGE:
NGF protein

NGF protein

Bio-activity:

Measured in a cell proliferation assay using TF-1 human erythroleukemic cells.
The ED50 for this effect is typically 0.2-2 ng/ml.
Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method
Stability: Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal: Ser 122
Molecular Mass:

The mature recombinant human β-NGF consists of 118 amino acids and has a predicted molecular mass of 13.2 kDa. β-NGF exists as a non-disulfide linked homodimer in solution

Formulation:

Lyophilized from sterile 20mM NaAc, 150mM NaCl ,  pH 5.5

β-NGF / Beta-NGF Protein Usage Guide

Storage: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

β-NGF / Beta-NGF Protein Related Products & Topics

Related Areas:

Neuroscience>>Neurotrophic Factor & Receptor>>Neurotrophin & Receptor>>NGF

Cancer>>Growth Factor & Receptor>>Neurotrophin & Receptor>>NGF

Proteins:

Molecule Species Description //For Detailed Info. and Price------CLICK! Cat. No
NGF/NGFB Human NGF Protein, Recombinant 11050-HNAC
NGF/NGFB Mouse NGF Protein, Recombinant 50385-MNAC

Antibodies:

Molecule Application Description //For Detailed Info. and Price------CLICK! Cat. No
Human
NGF/NGFB
WB, ELISA Rabbit Polyclonal Antibody 11050-RP01
Human
NGF/NGFB
WB, ELISA NGF / NGFB Antibody (Antigen Affinity Purified) 11050-RP02

β-NGF / Beta-NGF Protein Description

As the first one of a series of neurotrophic factors, nerve growth factor (NGF) is important for the development and maintenance of the sympathetic and sensory nervous systems. NGF was identified as a large complex consisting of three non-covalently linked subunits, α, β, and γ, among which, the β subunit, called β-NGF, was demonstrated to exhibits the growth stimulating activity of NGF. β-NGF is a target-derived secreted homodimeric protein of two 120-amino acid mature polypeptides after proteolytic removal of the signal and pro peptide. NGF acts via at least two receptors on the surface of cells, TrkA and p75 receptors to regulate neuronal survival, promote neurite outgrowth, and up-regulate certain neuronal functions such as mediation of pain and inflammation. In additon to its neurotropic activities, studies indicated that NGF may also have an important role in the regulation of the immune system. The synthesis of β-NGF in astrocytes is enhanced by various other cytokines including IL-1, TNF-α , PDGF and TGF-β .Defects in β-NGF are the cause of hereditary sensory and autonomic neuropathy type 5 (HSAN5) characterized by degeneration of dorsal root and autonomic ganglion cells, as well as sensory and/or autonomic abnormalities.

References

  1. Ullrich A. et al., 1983, Nature. 303: 821-5.
  2. Brain A. et al., 1999, J Neurosci. 19: 8207-18.
  3. Einarsdottir E. et al., 2004, Hum Mol Genet. 13: 799-805.
  4. Pedraza C E. et al., 2005, Am J Pathol. 166: 533-43.

 

β-NGF / Beta-NGF / NGF related areas, pathways, and other information

Neurotrophic Factor Proteins

Product name
Mouse / Human BDNF Protein (Native)
β-NGF / Beta-NGF Protein (Native)
Mouse β-NGF / Beta-NGF Protein (Native)
NTF3 / Neurotrophin 3 Protein (Native)
GDNF Protein
Rat GDNF Protein (His Tag)
Mouse CDNF / ARMETL1 Protein (His Tag)
CNTF Protein (His Tag)
Rat CNTF / Ciliary Neurotrophic Factor Protein (Native)
Mouse CNTF / Ciliary Neurotrophic Factor Protein (His Tag)
IL6ST / gp130 / CD130 Protein
Mouse IL6ST / CD130 Protein
Mouse IL6ST / gp130 / CD130 Protein (His Tag)
Rat gp130 / IL6ST / CD130 Protein
Rat gp130 / IL6ST / CD130 Protein (His Tag)
Mouse IL6ST / gp130 / CD130 Protein
Cynomolgus IL6ST / gp130 Protein
Cynomolgus IL6ST / gp130 Protein (His Tag)
IL6ST / gp130 / CD130 Protein
MANF / ARMET Protein (His Tag)
Mouse MANF / ARMET Protein (His Tag)
NRG1 Protein
NRG1 (aa 2-246) Protein
NRG1 (aa 177-241) Protein
NRG1 (aa 20-241) Protein
NRG1 (aa 20-241) Protein (His Tag)
NRG1 (aa 2-246) Protein
NRG1 (aa 2-246) Protein
Canine NRG1 (aa 176-240) Protein
Canine NRG1 (aa 19-240) Protein (His Tag)
Canine NRG1 (aa 19-240) Protein
Canine NRG1 / Neuregulin 1 (aa 19-240) Protein
NRG4 Protein
Mouse PTN / HB-GAM Protein
Pleiotrophin / PTN Protein(Native)
Mouse Pleiotrophin / PTN Protein (Native)

Neurotrophic factor Receptor Proteins

Product Name
Mouse NGFR / P75 Protein (His Tag)
Mouse NGFR / P75 Protein
NGFR / P75 Protein
NGFR/ P75 Protein (His Tag)
TrkA / NTRK1 Protein
TrkA / NTRK1 Protein (His Tag)
TrkA / NTRK1 Protein (aa 285-413)
TrkA / NTRK1 Protein (aa 194-413)
Rat TrkA / NTRK1 Protein (His Tag)
Mouse TrkA / NTRK1 Protein
Mouse TrkA / NTRK1 Protein (His Tag)
Rat TrkA / NTRK1 Protein
Canine TrkA / NTRK1 Protein
Canine TrkA / NTRK1 Protein (His Tag)
NTRK2 / Trk-B / TRKB Protein (His Tag)
NTRK2 / Trk-B / TRKB Protein
Mouse NTRK2 / TrkB Protein (His Tag)
Rat NTRK2 / TrkB Protein
Rat NTRK2 / TrkB Protein (His Tag)
Canine NTRK2 / TrkB Protein (His Tag)
TrkC / NTRK3 Protein
TrkC / NTRK3 Protein (His Tag)
Mouse NTRK3 / TrkC Protein (His Tag)
Mouse GFRA1 / GFR alpha-1 Protein (His Tag)
GFRA1 / GFRα1 / GDNFRA Protein (His Tag)
Rat GFRA1 / GFR alpha-1 Protein (His Tag)
Canine GFRA1 / GFR alpha-1 Protein (His Tag)
Rat GFRA1 / GFR alpha-1 Protein
GFRA2 / GFRα2 / GDNFRB Protein (His Tag)
Mouse GFRA2 / GFRα2 / GDNFRB Protein (His Tag)
GFRA3 / GFR-alpha-3 Protein
GFRA3 / GFR-alpha-3 Protein (His Tag)
Mouse GFRA3 / GFR-alpha-3 Protein
Mouse GFRA3 / GFR-alpha-3 Protein (His Tag)
CNTFR / CNTFR-alpha Protein (His Tag)
Rat CNTFR / CNTFR-alpha Protein (His Tag)
LIFR / CD118 Protein (His Tag)
Mouse LIFR / CD118 Protein (His Tag)
Rat LIFR Protein (His Tag)
Rat NCAM1 / CD56 Protein (His Tag)
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"