NGF Protein & Antibody (Nerve growth factor, NGFB, beta-NGF)

NGF Products

NGF Protein, Recombinant

Molecule	Species	Description	Cat. No
NGF/NGFB	Human	NGF Protein, Recombinant	11050-HNAC
NGF/NGFB	Mouse	NGF Protein, Recombinant	50385-MNAC

 11050-HNAC:

1. The ED₅₀ for this effect is typically 0.4-1.0 ng / ml  Measured in a cell proliferation assay using TF-1 human erythroleukemic cells.

2. The ED₅₀ for this effect is typically 1.07 ng / ml. Measured in a cell survival assay using PC-12 rat pheochromocytoma cells.

NGF Antibody

Molecule	Application	Description	Cat. No
Human NGF/NGFB	WB, ELISA	Rabbit Polyclonal Antibody	11050-RP01
Human NGF/NGFB	WB, ELISA	NGF / NGFB Antibody (Antigen Affinity Purified)	11050-RP02

NGF cDNA Clone

Molecule	Species	Description	Cat. No
NGF/NGFB	Human	Homo sapiens NGF cDNA Clone(NM_002506.2)	HG11050-C
NGF/NGFB	Mouse	Mus musculus NGF cDNA Clone	MG50385-M

All NGF Protein and Antibody

NGF Alternative Names

NGF, NGFB, Beta-NGF, HSAN5, MGC161426, MGC161428

NGF Related Areas

Neuroscience>>Neurotrophic Factor & Receptor>>Neurotrophin & Receptor>>NGF

Cancer>>Growth Factor & Receptor>>Neurotrophin & Receptor>>NGF

NGF Protein Related Products

Protein Products

Molecule	Species	Description
HGF	Human	HGF Protein, Recombinant
TPO/THPO	Human	TPO/THPO Protein, Recombinant
TPO/THPO	Human	TPO/THPO Protein, Recombinant
TPO/THPO	Mouse	TPO/THPO Protein, Recombinant
TPO/THPO	Cynomolgus	TPO/THPO Protein, Recombinant
WISP1	Human	WISP1 Protein, Recombinant

Antibody Products

Molecule	Application	Description
Human TPO/THPO	WB, ELISA	Mouse Monoclonal Antibody
Human TPO/THPO	WB, ELISA	Rabbit Monoclonal Antibody
Human TPO/THPO	ELISA	Rabbit Polyclonal Antibody
Human TPO/THPO	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)
Mouse TPO/THPO	ELISA	Rabbit Polyclonal Antibody
Mouse TPO/THPO	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)

cDNA Clone Products

Molecule	Species	Description
EG-VEGF	Human	Homo sapiens EG-VEGF cDNA Clone(NM_032414.2)
HGF	Human	Homo sapiens HGF cDNA Clone(NM_000601.4)
HGF	Mouse	Mus musculus HGF cDNA Clone
NOV/CCN3	Human	Homo sapiens NOV/CCN3 cDNA Clone(NM_002514.3)
NOV/CCN3	Mouse	Mus musculus CCN3/NOV/IGFBP9 cDNA Clone
PD-ECGF	Human	Homo sapiens PD-ECGF cDNA Clone(NM_001953.3)
TPO/THPO	Human	Homo sapiens TPO/THPO cDNA Clone(NM_000460.2)
TPO/THPO	Mouse	Mus musculus TPO/THPO cDNA Clone
WISP1	Human	Homo sapiens WISP1 cDNA Clone(NM_003882.2)

NGF Background

Nerve growth factor (NGF) is important for the development and maintenance of the sympathetic and sensory nervous systems. NGF protein was identified as a large complex consisting of three non-covalently linked subunits, α, β, and γ, among which, the β subunit, called β-NGF (beta-NGF), was demonstrated to exhibits the growth stimulating activity of NGF protein. NGFB/beta-NGF gene is a member of the NGF-beta family and encodes a secreted protein which homodimerizes and is incorporated into a larger complex. NGF protein acts via at least two receptors on the surface of cells (TrkA and p75 receptors) to regulate neuronal survival, promote neurite outgrowth, and up-regulate certain neuronal functions such as mediation of pain and inflammation. In addition, previous studies indicated that NGF may also have an important role in the regulation of the immune system.

NGF Related Studies

1. Castellanos MR, et al. (2003) Evaluation of the neurorestorative effects of the murine beta-nerve growth factor infusions in old rat with cognitive deficit. Biochem Biophys Res Commun. 312(4): 867-72.
2. Wang TH, et al. (2008) Effects of pcDNA3-beta-NGF gene-modified BMSC on the rat model of Parkinson's disease. J Mol Neurosci. 35(2): 161-9.
3. Xanthos DN, et al. (2009) The roles of nerve growth factor and cholecystokinin in the enhancement of morphine analgesia in a rodent model of central nervous system inflammation. Neuropharmacology. 56(3): 684-91.
4. Perrard MH, et al. (2009) Redundancy of the effect of TGFbeta1 and beta-NGF on the second meiotic division of rat spermatocytes. Microsc Res Tech. 72(8): 596-602.