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NGF / NGFB Neutralizing Antibody

  • NGF / NGFB Neutralizing Antibody
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Human NGF Antibody Product Information
Immunogen:Recombinant Human NGF / NGFB Protein (Catalog#11050-HNAC)
Clone ID:R711
Ig Type:Rabbit IgG
Endotoxin:< 3 EU/mg
Formulation:0.2 μm filtered solution in Histidine and Arginine buffer containing 120mM NaCl, 0.02% Tween 80, pH6.0
Preparation:This antibody was obtained from a rabbit immunized with purified, recombinant Human NGF / NGFB (rh NGF / NGFB; Catalog#11050-HNAC; NP_002497.2; Ser122-Arg239) and was produced using recombinant antibody technology.
Human NGF Antibody Neutralization Application Image
NGF / NGFB Neutralizing Antibody
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Cell Proliferation Induced by β­NGF was Neutralized by Human β­NGF Antibody. Recombinant Human β­NGF (Catalog 11050-HNAC) stimulates proliferation in the TF­1 human erythroleukemic cell line. Proliferation elicited by Recombinant Human β­NGF (10 ng/mL) is neutralized by increasing concentrations of Rabbit Anti­Human β­NGF Monoclonal Antibody (Catalog 11050-R711). The IC50 is typically 0.048­0.19 µg/mL.
Other NGF Antibody Products
Immunochemical staining of human CD40 in human tonsil with rabbit polyclonal antibody (0.5 µg/mL, formalin-fixed paraffin embedded sections).
NGF/NGFB/beta-NGF Background

Nerve growth factor (NGF) is important for the development and maintenance of the sympathetic and sensory nervous systems. NGF protein was identified as a large complex consisting of three non-covalently linked subunits, α, β, and γ, among which, the β subunit, called β-NGF (beta-NGF), was demonstrated to exhibits the growth stimulating activity of NGF protein. NGFB/beta-NGF gene is a member of the NGF-beta family and encodes a secreted protein which homodimerizes and is incorporated into a larger complex. NGF protein acts via at least two receptors on the surface of cells (TrkA and p75 receptors) to regulate neuronal survival, promote neurite outgrowth, and up-regulate certain neuronal functions such as mediation of pain and inflammation. In addition, previous studies indicated that NGF may also have an important role in the regulation of the immune system.

Human NGF/NGFB/beta-NGF References
  • Castellanos MR, et al. (2003) Evaluation of the neurorestorative effects of the murine beta-nerve growth factor infusions in old rat with cognitive deficit. Biochem Biophys Res Commun. 312(4): 867-72.
  • Wang TH, et al. (2008) Effects of pcDNA3-beta-NGF gene-modified BMSC on the rat model of Parkinson's disease. J Mol Neurosci. 35(2): 161-9.
  • Perrard MH, et al. (2009) Redundancy of the effect of TGFbeta1 and beta-NGF on the second meiotic division of rat spermatocytes. Microsc Res Tech. 72(8): 596-602.
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    Catalog: 11050-R711-500
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    Datasheet & Documentation

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