NETO1 Protein & Antibody

Neuropilin (NRP) and tolloid (TLL)-like 1

NETO1 Products

NETO1 Protein, Recombinant

Molecule	Species	Description	Cat. No
NETO1	Human	NETO1/BTCL1 Protein, Recombinant	11562-H08H

NETO1 Antibody

Molecule	Application	Description	Cat. No
Human NETO1	WB, ELISA	NETO1 Antibody, Rabbit PAb	11562-RP01
Human NETO1	WB, ELISA	NETO1 Antibody, Rabbit PAb (Antigen Affinity Purified)	11562-RP02

NETO1 cDNA Clone

Molecule	Species	Description	Cat. No
NETO1	Human	Homo sapiens NETO1 cDNA Clone	HG11562-M
NETO1	Mouse	Mouse NETO1 cDNA Clone / ORF Clone	MG50948-G

NETO1 Alternative Names

NETO1, BCTL1, BTCL1 [Homo sapiens]

Neto1, AI851453, Btcl1, C130005O10Rik [Mus musculus]

NETO1 Background

Neuropilin tolloid-like 1 (NETO1), a complement C1r/C1s, Uegf, Bmp1 (CUB) domain-containing transmembrane protein, is a novel component of the NMDAR complex critical for maintaining the abundance of NR2A-containing NMDARs in the postsynaptic density. The N-methyl-D-aspartate receptor (NMDAR), a major excitatory ligand-gated ion channel in the central nervous system (CNS), is a principal mediator of synaptic plasticity. Both NETO1 and NETO2 share an identical and unique domain structure thus representing a novel subfamily of CUB- and LDLa-containing proteins. The cytoplasmic domains of NETO1 and NETO2 are not homologous to other known protein sequences but contain a conserved FXNPXY-like motif, which is essential for the internalization of clathrin coated pits during endocytosis or alternatively, may be implicated in intracellular signaling pathways. NETO1 and NETO2, have marked effects on receptor properties, increasing further the potential diversity of Kainate receptors (KARs) functional properties. NETO1 involves in the development and/or maintenance of neuronal circuitry. NETO1 regulates long-term NMDA receptor-dependent synaptic plasticity and cognition, at least in the context of spatial learning and memory.

NETO1 Related Studies

1. Stöhr H, et al. (2002) A novel gene encoding a putative transmembrane protein with two extracellular CUB domains and a low-density lipoprotein class A module: isolation of alternatively spliced isoforms in retina and brain. Gene. 286(2): 223-31.
2. Ng D, et al.d for synaptic plasticity and learning. PLoS Biol. 7(2): e41.
3. Perrais D, et al. (2010) Gating and permeation of kainate receptors: differences unveiled. Trends Pharmacol Sci. 31(11): 516-22.