NEGR1

Neuronal Growth Regulator 1, NEGR1, also known as neurotractin, or KILON, which belongs to the immunoglobulin superfamily, IgLON family. This GPI-linked cell surface glycoprotein NEGR1 is composed of three Ig-like domains and belongs to the IgLON subgroup of neural IgSF members. It is expressed in two isoforms with apparent molecular masses of 50 and 37 kD, termed L-form and S-form, respectively. NEGR1/Neurotractin participates in the regulation of neurite outgrowth in the developing brain, and is expressed on neurites of primary hippocampal neurons. Neurotractin/KILON is a trans-neural growth-promoting factor for outgrowing axons following hippocampal denervation. KILON (kindred of IgLON) and opioid-binding cell adhesion molecule belong to the IgLON subgroup of immunoglobulin superfamily together with the limbic system-associated membrane protein and neurotrimin. The alteration of modulatory function of KILON/NEGR1 for the number of dendritic synapses concomitant with changes in its localization and detergent solubility during neuronal culture development. In addition to its reported role in the brain, NEGR1 is also expressed in subcutaneous adipose tissue and acts as a central 'hub' in an obesity-related transcript network.

NEGR1 Related Areas

Tumor Antigen Reagents >>NEGR1

NEGR1 Alternative Names

NEGR1, UNQ2433, DMML2433, IGLON4, KILON, MGC46680, Ntra [Homo sapiens]

Negr1, 5330422G01Rik, KILON, Ntra, mKIAA3001 [Mus musculus]

Summaries for NEGR1

Entrez Gene summary for NEGR1:

OMIM - description for NEGR1:

Funatsu et al. (1999) cloned rat Negr1, which they called Kilon. The deduced 348-amino acid protein has an N-terminal signal sequence, 3 immunoglobulin (Ig)-like C2 domains, 6 putative glycosylation sites, and a putative C-terminal glycosylphosphatidylinositol (GPI) anchoring signal. It also has 3 sets of cysteines that are likely to form intradomain disulfide linkages in each of its Ig-like domains, which is a characteristic of IgLON (see 607938) family proteins. Western blot analysis detected Kilon at an apparent molecular mass of 46 kD in adult cerebrum, brainstem, and hippocampus, with much lower expression in cerebellum. In adult rat cerebral cortex and hippocampus, Kilon was predominantly expressed in the large pyramidal neurons. In cerebellum, Kilon was expressed in Purkinje cell dendrites and soma. Embryonic rat showed much lower Kilon expression.

Wikipedia summary for NEGR1:

Neuronal growth regulator 1 also known as NEGR1 is a protein which in humans is encoded by the NEGR1 gene

Human NEGR1 Protein General Information

 

• Protein names: Submitted name: NEGR1 protein
• Sequence length: 354 AA.
• Domain: Immunoglobulin domain Repeat Signal
• Sequence similarities: Belongs to the immunoglobulin superfamily. IgLON family. Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
• Subcellular location: Cell membrane; Lipid-anchor › GPI-anchor

General information above from UniProt

Function for NEGR1 Protein

UniProtKB:

May be involved in cell-adhesion. May function as a trans-neural growth-promoting factor in regenerative axon sprouting in the mammalian brain

Genatlas:

Homology for human NEGR1

• homolog to murine Negr1
• homolog to rattus LOC59318