NEGR1 Protein

Neuronal Growth Regulator 1

NEGR1 Products

NEGR1 Protein, Recombinant

Molecule	Species	Description	Cat. No
NEGR1	Human	NEGR1 Protein, Recombinant	11181-H08H
NEGR1	Mouse	NEGR1 Protein, Recombinant	50601-M08H

NEGR1 cDNA Clone

Molecule	Species	Description	Cat. No
NEGR1	Human	Homo sapiens NEGR1 cDNA Clone	HG11181-M
NEGR1	Mouse	Mus musculus NEGR1 cDNA Clone	MG50601-M

NEGR1 Alternative Names

NEGR1, UNQ2433, DMML2433, IGLON4, KILON, MGC46680, Ntra [Homo sapiens]

Negr1, 5330422G01Rik, KILON, Ntra, mKIAA3001 [Mus musculus]

NEGR1 Background

Neuronal Growth Regulator 1, NEGR1, also known as neurotractin, or KILON, which belongs to the immunoglobulin superfamily, IgLON family. This GPI-linked cell surface glycoprotein NEGR1 is composed of three Ig-like domains and belongs to the IgLON subgroup of neural IgSF members. It is expressed in two isoforms with apparent molecular masses of 50 and 37 kD, termed L-form and S-form, respectively. NEGR1/Neurotractin participates in the regulation of neurite outgrowth in the developing brain, and is expressed on neurites of primary hippocampal neurons. Neurotractin/KILON is a trans-neural growth-promoting factor for outgrowing axons following hippocampal denervation. KILON (kindred of IgLON) and opioid-binding cell adhesion molecule belong to the IgLON subgroup of immunoglobulin superfamily together with the limbic system-associated membrane protein and neurotrimin. The alteration of modulatory function of KILON/NEGR1 for the number of dendritic synapses concomitant with changes in its localization and detergent solubility during neuronal culture development. In addition to its reported role in the brain, NEGR1 is also expressed in subcutaneous adipose tissue and acts as a central 'hub' in an obesity-related transcript network.

NEGR1 Related Studies

1. Marg A, et al. (1999) Neurotractin, a novel neurite outgrowth-promoting Ig-like protein that interacts with CEPU-1 and LAMP. J Cell Biol. 145(4): 865-76.
2. Miyata S, et al. (2003) Biochemical and ultrastructural analyses of IgLON cell adhesion molecules, Kilon and OBCAM in the rat brain. Neuroscience. 117(3): 645-58.
3. Schäfer M, et al. (2005) Neurotractin/kilon promotes neurite outgrowth and is expressed on reactive astrocytes after entorhinal cortex lesion. Mol Cell Neurosci. 29(4): 580-90.
4. Hashimoto T, et al. (2008) IgLON cell adhesion molecule Kilon is a crucial modulator for synapse number in hippocampal neurons. Brain Res. 1224: 1-11.