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Mouse Nicastrin / NCSTN Protein (Fc Tag)
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Mouse Nicastrin / NCSTN Protein (Fc Tag) PDF Download

Catalog   Size (Price) Quantity In Stock Operation
50934-M02H  
YES   
 

Protein Production & Purification Service | Recombinant Cytokines & Growth Factors

Nicastrin Protein Datasheet

 

NCSTN / Nicastrin Protein Price Inquiry ( Available Sizes )

NCSTN / Nicastrin Protein Product Information

Synonym : NCSTN
Protein Construction:

A DNA sequence encoding the mouse NCSTN (P57716) (Met1- Glu668) was expressed, fused with the Fc region of human IgG1 at the C-terminus.

Source: Mouse
Expression Host: Human Cells

NCSTN / Nicastrin Protein QC Testing

Purity: > 95% as determined by SDS-PAGE SDS-PAGE:
SDS-PAGE

NCSTN / Nicastrin protein

Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method
Stability: Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal: Gly 28
Molecular Mass:

The recombinant mouse NCSTN/Fc is a disulfide-linked homodimer. The reduced monomer comprises 882 amino acids and has a predicted molecular mass of 98.5 kDa. The apparent molecular mass of the protein is approximately 117 kDa in SDS-PAGE under reducing conditions due to glycosylation.

Formulation: Lyophilized from sterile PBS, pH7.4.
  1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
  2. Please contact us for any concerns or special requirements.

NCSTN / Nicastrin Protein Usage Guide

Storage: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

NCSTN / Nicastrin Protein Related Products & Topics

Related Areas:

Signal Transduction>>Notch Signaling Pathway>>Nicastrin/NCSTN

Stem Cell>>Notch Signaling Pathway>>Nicastrin/NCSTN

Proteins:

Molecule Species Description //For Detailed Info. and Price------CLICK! Cat. No
Nicastrin/NCSTN Human Nicastrin/NCSTN Protein, Recombinant 11183-H08H
Nicastrin/NCSTN Mouse NCSTN / Nicastrin Protein, Recombinant 50934-M02H
Nicastrin/NCSTN Mouse NCSTN / Nicastrin Protein, Recombinant 50934-M08H

Antibodies:

Molecule Application Description //For Detailed Info. and Price------CLICK! Cat. No
Human
Nicastrin/NCSTN
WB, ELISA Rabbit Polyclonal Antibody 11183-RP01
Human
Nicastrin/NCSTN
WB, ELISA Rabbit Polyclonal Antibody (Antigen Affinity Purified) 11183-RP02
Human
Nicastrin/NCSTN
WB, ELISA Nicastrin / NCSTN Antibody 11183-R007

NCSTN / Nicastrin Protein Description

Nicastrin, also known as NCSTN, is a single-pass type I  membrane protein which belongs to the nicastrin family. Nicastrin was named after the Italian village Nicastro, reflecting the fact that Alzheimer's disease was described in 1963 after studying descendants of an extended family originating in the village of Nicastro that had Familial Alzheimer's Disease (FAD). Nicastrin is a protein that is part of the gamma secretase protein complex, which is one of the proteases involved in processing amyloid precursor protein (APP) to the short Alzheimer's disease-associated peptide amyloid beta. Nicastrin may represent a stabilizing cofactor required for the assembly of the gamma-secretase complex. The other proteins in the complex are presenilin, which is the catalytically active component of the complex, APH-1, and PEN-2. Nicastrin itself is not catalytically active, but instead promotes the maturation and proper trafficking of the other proteins in the complex, all of which undergo significant post-translational modification before becoming active in the cell. Nicastrin has also been identified as a regulator of neprilysin, an enzyme involved in the degradation of amyloid beta fragment.

References

  1. Feldman RG. et al., 1963, Neurology. 13: 811-24.
  2. Satoh J. et al., 2001, Neuropathology. 21: 115-22.
  3. Zhang YW. et al., 2005, J Biol Chem. 280 (17): 17020-6.
  4. Kaether C. et al., 2006, Neurodegener Dis. 3 (4-5): 275-83.
  5. Chi A. et al., 2006, J. Proteome Res. 5: 3135-44.
 
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"