NCR3 Protein & Antibody (NKp30, CD337)

Natural Cytotoxicity Triggering Receptor 3 (Natural Killer Cell p30-related protein, Cluster of Differentiation 337)

NCR3 Products

NCR3 Protein, Recombinant

Molecule	Species	Description	Cat. No
NCR3/NKp30/CD337	Human	NCR3/NKp30/CD337/Fc Protein, Recombinant	10480-H03H
NCR3/NKp30/CD337	Human	NCR3/NKp30/CD337 Protein, Recombinant	10480-H08H

NCR3 Antibody

Molecule	Application	Description	Cat. No
Human NCR3/NKp30	WB, ELISA	Rabbit Polyclonal Antibody	10480-RP01
Human NCR3/NKp30	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)	10480-RP02

NCR3 cDNA Clone

Molecule	Species	Description	Cat. No
NCR3/NKp30/CD337	Human	Homo sapiens NCR3/NKp30/CD337 cDNA Clone(NM_147130.1)	HG10480-M

NCR3 Alternative Names

NCR3, NKp30, CD337, DAAP-90L16.3, 1C7, LY117, MALS [Homo sapiens]

Ncr3, 1C7, Lst1, Ly117 [Mus musculus]

Ncr3, Nkp30, 1C7 [Rattus norvegicus]

NCR3 Related Areas

Immunology>>Innate Immunity>>Natural Killer Cell (NK Cell)>>NCR3/NKp30/CD337

Immunology>>Cluster of Differentiation>>Natural Killer (NK) Cell CD Antigen>>NCR3/NKp30/CD337

NCR3 Background

Natural Cytotoxicity Triggering Receptor 3, NCR3, also known as NKp30, or CD337, is a natural cytotoxicity receptor, expressed on subsets of human peripheral blood NK cells, involved in NK cell killing of tumor cells and immature dendritic cells. The cellular ligand for NKp30 has remained elusive, but the membrane-associated heparan sulfate (HS) proteoglycans are involved in the recognition of cellular targets by NKp30 was recently reported. NKp30 is a member of the immunoglobulin superfamily and one of three existing natural cytotoxicity-triggering receptors. NKp30 is a glycosylated protein and is thought to be selectively expressed in resting and activated natural killer cells. NKp30 is a stimulatory receptor on human NK cells implicated in tumor immunity, and is capable of promoting or terminating dendritic cell maturation. NCR3 may play a role in inflammatory and infectious diseases.

NCR3 Related Studies

1. Warren HS, et al. (2005) Evidence that the cellular ligand for the human NK cell activation receptor NKp30 is not a heparan sulfate glycosaminoglycan. J Immunol. 175(1): 207-12.
2. Mulcahy H, et al. (2006) LST1 and NCR3 expression in autoimmune inflammation and in response to IFN-gamma, LPS and microbial infection. Immunogenetics. 57(12): 893-903.
3. Hsieh CL, et al. (2006) NKp30 is a functional activation receptor on a subset of rat natural killer cells. Eur J Immunol. 36(8): 2170-80.
4. Ponnampalam AP, et al. (2008) Identification and hormonal regulation of a novel form of NKp30 in human endometrial epithelium. Eur J Immunol. 38(1): 216-26.