Anti-NKp30 Antibody

Cat: 10480-R012
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Anti-NKp30 Antibody (Rabbit Monoclonal antibody) General Information
Product name
Anti-NKp30 Antibody
Validated applications
WB,ELISA
Species reactivity
Reacts with: Human
Specificity
Human NKp30
Immunogen
Recombinant Human NCR3 / CD337 Protein (Catalog#10480-H08H)
Preparation
This antibody was obtained from a rabbit immunized with purified, recombinant Human NCR3 / CD337 (rh NCR3 / CD337; Catalog#10480-H08H; NP_667341.1; Met1-Gly135).
Source
Monoclonal Rabbit IgG Clone #012
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-NKp30 Antibody (Rabbit Monoclonal antibody) Validated Applications
Application Dilution Notes
WB 1:500-1:1000  
ELISA 1:25000-1:50000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-NKp30 Antibody (Rabbit Monoclonal antibody) Images
Human NCR3(CD337) Western blot (WB) 18971

Anti-NCR3 rabbit monoclonal antibody at 1:500 dilution

Lane A: K562 Whole Cell Lysate

Lysates/proteins at 30 μg per lane.

Secondary

Goat Anti-Rabbit IgG H&L (Dylight800) at 1/10000 dilution.

Developed using the Odyssey technique.

Performed under reducing conditions.

Predicted band size:22 kDa

Observed band size:14 kDa

Anti-NKp30 Antibody Alternative Names
Anti-1C7 Antibody;Anti-CD337 Antibody;Anti-DAAP-90L16.3 Antibody;Anti-LY117 Antibody;Anti-MALS Antibody;Anti-NCR3 Antibody;Anti-NKp30 Antibody
NKp30 Background Information

Natural Cytotoxicity Triggering Receptor 3, NCR3, also known as NKp30, or CD337, is a natural cytotoxicity receptor, expressed on subsets of human peripheral blood NK cells, involved in NK cell killing of tumor cells and immature dendritic cells. The cellular ligand for NKp30 has remained elusive, but the membrane-associated heparan sulfate (HS) proteoglycans are involved in the recognition of cellular targets by NKp30 was recently reported. NKp30 is a member of the immunoglobulin superfamily and one of three existing natural cytotoxicity-triggering receptors. NKp30 is a glycosylated protein and is thought to be selectively expressed in resting and activated natural killer cells. NKp30 is a stimulatory receptor on human NK cells implicated in tumor immunity, and is capable of promoting or terminating dendritic cell maturation. NCR3 may play a role in inflammatory and infectious diseases.

Full Name
natural cytotoxicity triggering receptor 3
References
  • Warren HS, et al. (2005) Evidence that the cellular ligand for the human NK cell activation receptor NKp30 is not a heparan sulfate glycosaminoglycan. J Immunol. 175(1): 207-12.
  • Mulcahy H, et al. (2006) LST1 and NCR3 expression in autoimmune inflammation and in response to IFN-gamma, LPS and microbial infection. Immunogenetics. 57(12): 893-903.
  • Hsieh CL, et al. (2006) NKp30 is a functional activation receptor on a subset of rat natural killer cells. Eur J Immunol. 36(8): 2170-80.
  • Ponnampalam AP, et al. (2008) Identification and hormonal regulation of a novel form of NKp30 in human endometrial epithelium. Eur J Immunol. 38(1): 216-26.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-NKp30 Antibody Rabbit Polyclonal ELISA 81349-RP01
    Anti-NKp30 Antibody Rabbit Polyclonal ELISA 10480-RP02
    Anti-NKp30 Antibody Rabbit Polyclonal ELISA 10480-RP01
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