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Natural cytotoxicity triggering receptor 1 Protein Datasheet
NCR1 Protein Price Inquiry ( Available Sizes )
NCR1 Protein Product Information
|Synonym :||NCR1, Ar1, Kilr1, Ly94|
A DNA sequence encoding the rat NCR1 (Q9Z0H5) (Met1-Asn255) was expressed, fused with the Fc region of human IgG1 at the C-terminus.
|Expression Host:||Human Cells|
NCR1 Protein QC Testing
|Purity:||(73.6+23)%as determined by SDS-PAGE||SDS-PAGE:
|Endotoxin:||< 1.0 EU per μg of the protein as determined by the LAL method|
|Stability:||Samples are stable for up to twelve months from date of receipt at -70℃|
|Predicted N terminal:||Gln 17|
The recombinant rat NCR1/Fc is a disulfide-linked homodimer. The reduced monomer comprises 480 amino acids and has a predicted molecular mass of 54.1 kDa. The apparent molecular mass of the protein is approximately 65 and 36 kDa in SDS-PAGE under reducing conditions.
|Formulation:||Lyophilized from sterile PBS, pH7.4.
NCR1 Protein Usage Guide
|Storage:||Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.|
|Reconstitution:||A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.|
NCR1 Protein Related Products & Topics
NCR1 Protein Description
NCR1, also known as NK-p46 and CD335, is called natural cytotoxicity receptors (NCR) together with NCR3 and NCR2. NKp46 has two extracellular Ig-like domains followed by a ~40 residue stalk region, a type I transmembrane domain, and a short cytoplasmic tail. It has been implicated in NK cell-mediated lysis of several autologous tumor cells, pathogen-infected cell lines and mononuclear phagocytes infected with an intracellular bacterium. NKp46 is a surface receptor involved in NK-cell cell death by apoptosis. NKp46 and its coreceptor CD59 together activate cytotoxicity of human NK-cells, their engagement results in tyrosine phosphorylation of CD3-zeta chains associated with NKp46.
- Carbone E. et al., 2005, Blood. 105 (1): 251-8.
- Sivori S. et al., 1997, J Exp Med. 186 (7): 1129-36.
- Biassoni R. et al., 2004, J Cell Mol Med. 7 (4): 376-87.