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NCR1 (NK-p46)

NCR1, also known as NK-p46 and CD335, is a natural cytotoxicity receptor(NCR). NCRs are type I transmembrane proteins with 1-2 extracellular immunoglobulin domains, a transmembrane domain containing a positively charged amino acid residue, and a short cytoplasmic tail. All are expressed almost exclusively by NK cells and play a major role in triggering NK-mediated killing of most tumor cell lines. NKp46 has two extracellular Ig-like domains followed by a ~40 residue stalk region, a type I transmembrane domain, and a short cytoplasmic tail. NKp46 has been implicated in NK cell-mediated lysis of several autologous tumor cells, pathogen-infected cell lines and mononuclear phagocytes infected with an intracellular bacterium.

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NCR1 (NK-p46) Alternative Names

XXbac-BCX195L8.10-004, CD335, LY94, NK-p46, NKP46, NK cell-activating receptor, lymphocyte antigen 94 homolog (activating NK-receptor, NK-p46), natural killer cell p46-related protein [Homo sapiens]

Ly94, NKp46, MAR1 (mouse activating receptor 1), NK-p46, activating receptor 1, lymphocyte antigen 94, mAR-1, mNKp46, natural killer cell p46-related protein [Mus musculus]

Summaries for NCR1 (NK-p46)

Wikipedia summary for NCR1 (NK-p46):

Natural cytotoxicity triggering receptor 1 is a protein that in humans is encoded by the NCR1 gene. NCR1 has also been designated as CD335 (cluster of differentiation 335).

Human NCR1 (NK-p46) Protein General Information


Protein names

Natural cytotoxicity triggering receptor 1
Short name=NCR1

Sequence length

304 AA.


Immunoglobulin domain
Transmembrane helix

Sequence similarities:

Belongs to the natural cytotoxicity receptor (NCR) family.
Contains 2 Ig-like (immunoglobulin-like) domains.

Post-translational modification:


Subunit structure

Interacts with CD247 and FCER1G.

Subcellular location: Cell membrane; Single-pass type I membrane protein
Tissue specificity

Selectively expressed by both resting and activated NK cells.

General information above from UniProt

Function for NCR1 (NK-p46) Protein


NCR1 is cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis.


  • NCR1 is major activating receptor involved in the recognition and lysis of tumor cells
  • NCR1 has a role in NK cell activation
  • NCR1 is involved in NK cell activation mediated by non-HLA class I ligands
  • NCR1 plays critical and differential roles of NCR1- and NCR3-activating receptors expressed by uterine NK cells in early pregnancy
  • NCR1, NCR2, NCR3 are thought to be NK lineage restricted
  • NCR1 with NCR2 and NCR3, are type I transmembrane proteins that signal NK cell activation via ITAM-containing adapter proteins in response to stress- and pathogen-induced ligands
  • NCR1 is essential for the development of type 1 diabetes and is a potential new therapeutic modalities for this disease
  • NCR1 is specific NK killer receptor that recognizes various influenza hemagglutinins and unknown tumor ligands
  • NCR1 is major killer receptor expressed by NK cells, recognizing an unknown ligand expressed by pancreatic beta cells and in the absence of NCR1, or when its activity is blocked, diabetes development is inhibited
  • NCR1 is cell surface receptor expressed on natural killer (NK) cells, on a minute subset of T cells, and on a population of innate lymphoid cells that produce IL22
  • NCR1 is critical for the subsequent development of antiviral and antibacterial T cell responses, suggesting that the regulation of NK cell function by NCR1 allows for the optimal development of adaptive immune responses

Homology for human NCR1 (NK-p46)

  • homolog to murine Ly94
  • homolog to Drosophila cg7565

Phenotype Information for NCR1 (NK-p46)

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