NCKIPSD cDNA ORF Clone in Cloning Vector, Human

Cat: HG13642-G
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NCKIPSD cDNA ORF Clone in Cloning Vector, Human General Information
Gene
Species
Human
NCBI Ref Seq
RefSeq ORF Size
2148 bp
Sequence Description
Identical with the Gene Bank Ref. ID sequence.
Description
Full length Clone DNA of Human NCK interacting protein with SH3 domain.
Plasmid
Vector
pGEM-T Vector
Sequencing Primers
SP6 and T7 or M13-47 and RV-M
Quality Control
The plasmid is confirmed by full-length sequencing.
Screening
Antibiotic in E.coli
Ampicillin
Storage & Shipping
Shipping
Each tube contains lyophilized plasmid.
Storage
The lyophilized plasmid can be stored at ambient temperature for three months.
NCKIPSD cDNA ORF Neucleotide Sequence and Amino Acid Sequence Information

**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**

NCKIPSD cDNA ORF Clone in Cloning Vector, Human Alternative Names
AF3P21 cDNA ORF Clone, Human;DIP cDNA ORF Clone, Human;DIP1 cDNA ORF Clone, Human;ORF1 cDNA ORF Clone, Human;SPIN90 cDNA ORF Clone, Human;VIP54 cDNA ORF Clone, Human;WASLBP cDNA ORF Clone, Human;WISH cDNA ORF Clone, Human
NCKIPSD Background Information

NCKIPSD is localized exclusively in the cell nucleus. It plays a role in signal transduction, and may function in the maintenance of sarcomeres and in the assembly of myofibrils into sarcomeres. NCKIPSD also plays an important role in stress fiber formation. NCKIPSD gene is involved in therapy-related leukemia by a chromosomal translocation t(3;11)(p21;q23) that involves this gene and the myeloid/lymphoid leukemia gene. Alternative splicing occurs in this locus and two transcript variants encoding distinct isoforms have been identified. NCKIPSD is a SH3 domain protein. Fas ligand is a cytotoxic effector molecule of T and NK cells which is characterized by an intracellular N-terminal polyproline region that serves as a docking site for SH3 and WW domain proteins. Several previously described Fas ligand-interacting SH3 domain proteins turned out to be crucial for the regulation of storage, expression and function of the death factor. Recent observations, however, indicate that Fas ligand is also subject to posttranslational modifications including shedding and intramembrane proteolysis.

Full Name
NCK interacting protein with SH3 domain
References
  • Satoh, S, et al. (2001) mDia-interacting protein acts downstream of Rho-mDia and modifies Src activation and stress fiber formation. J Biol Chem. 276(42):39290-4.
  • de Bernard M, et al. (2000) The VacA toxin of Helicobacter pylori identifies a new intermediate filament-interacting protein. EMBO J. 19(1):48-56.
  • Sano K, et al. (2000) Novel SH3 protein encoded by the AF3p21 gene is fused to the mixed lineage leukemia protein in a therapy-related leukemia with t(3;11) (p21;q23). Blood. 95(3): 1066-8.
  • Voss M, et al. (2009) Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening. BMC Immunol. 10:53.
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    NCKIPSD cDNA ORF Clone, Human, Related Products

    Product Name Catalog#(PDF)
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    NCKIPSD cDNA ORF Clone, Human, C-GFPSpark® tag HG13642-ACG
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    NCKIPSD cDNA ORF Clone, Human, N-HA tag HG13642-NY
    NCKIPSD cDNA ORF Clone, Human, C-Myc tag HG13642-CM
    NCKIPSD cDNA ORF Clone, Human, N-Myc tag HG13642-NM
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