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Human NBL1 / DAND1 / DAN ELISA Pair Set
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Human NBL1 / DAND1 / DAN ELISA Pair Set (Cytokine) PDF Download

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Human NBL1 / DAND1 / DAN ELISA Pair Set

Order or Inquire for NBL1 / DAND1 / DAN ELISA Pair Set
High affinity Human NBL1 / DAND1 / DAN ELISA Pair Set
Detection limit - 46.9 pg/ml
Affordable price and 30%-80% cost saving for Bulk order
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Human NBL1 / DAND1 / DAN ELISA Pair Set Related Products & Topics

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Background

Human differential screening-selected gene aberrative in neuroblastoma (DAN) originally isolated from a normal lung cDNA library, is a the prototypical member of the DAN family of secreted glycoproteins. There are at least five mammalian protein members in the evolutionarily conserved Dan family including DAN, Gremlin/DRM, Cer1 (Cerberus-related), Dante and PRDC (protein related to DAN and cereberus), and share the C-terminal cystine-knot motif. As a secreted glycoprotein, DAN acts as the BMPs (bone morphogenetic protein) antagonist by binding to BMPs and preventing their interactions with signaling receptor complexes, and accordingly regulates the processes of embryonic development and tissue differentiation. In addition, it has been reported that DAN also acts as an inhibitor of cell cycle progression and monocyte chemotaxis, and is closely involved in human neuroblastoma differentiation. DAN thus is regarded as a novel candidate of tumour suppressor.

 
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