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NBL1 / DAND1 / DAN Antibody, Rabbit PAb, Antigen Affinity Purified

  • NBL1 / DAND1 / DAN Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
  • NBL1 / DAND1 / DAN Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
  • NBL1 / DAND1 / DAN Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
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Human NBL1/DAN Antibody Product Information
Immunogen:Recombinant Human NBL1 protein (Catalog#10169-H08H)
Clone ID:
Ig Type:Rabbit IgG
Concentration:
Endotoxin:
Formulation:0.2 μm filtered solution in PBS with 5% trehalose
Preparation:Produced in rabbits immunized with purified, recombinant Human NBL1 / DAN (rh NBL1; Catalog#10169-H08H; NP_005371.1; Met 1-Asp 180). NBL1 specific IgG was purified by human NBL1 affinity chromatography.
Human NBL1/DAN Antibody IHC Application Image
NBL1 / DAND1 / DAN Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
[Click to enlarge image]
Caption:
Immunochemical staining of human DAN in human hepatoma with rabbit polyclonal antibody (5 µg/mL, formalin-fixed paraffin embedded sections).
NBL1 / DAND1 / DAN Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
[Click to enlarge image]
Caption:
Immunochemical staining of human DAN in human kidney with rabbit polyclonal antibody (5 µg/mL, formalin-fixed paraffin embedded sections).
NBL1 / DAND1 / DAN Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
[Click to enlarge image]
Caption:
Immunochemical staining of human DAN in human lung with rabbit polyclonal antibody (5 µg/mL, formalin-fixed paraffin embedded sections).
Other NBL1/DAN Antibody Products
NBL1/DAND1 Background

The Dan (Differential screening-selected gene aberrative in neuroblastoma, also known as N03) gene was first identified as the putative rat tumor suppressor gene and encodes a protein structurally related to Cerberus and Gremlin in vertebrates. It is a founding member of the DAN family of secreted proteins, acts as an inhibitor of cell cycle progression and is closely involved in retinoic acid-induced neuroblastoma differentiation. There are at least five mammalian protein members in the evolutionarily conserved Dan family including DAN, Gremlin/DRM, Cer1 (Cerberus-related), Dante and PRDC (protein related to DAN and cereberus), and share the C-terminal cystine-knot motif. As a secreted glycoprotein, DAN is a member of a class of glycoproteins shown to be secreted inhibitors of the transforming growth factor-beta (TGF-beta) and bone morphogenic protein pathways. It binds to BMPs and preventing their interactions with signaling receptor complexes, and accordingly regulates the processes of embryonic development and tissue differentiation. DAN gene product may have an important role in regulation of the entry of cells into the S phase. In addition, DAN gene product possesses an ability to revert phenotypes of transformed rat fibroblasts and represents a candidate tumour suppressor gene for neuroblastoma.

Human NBL1/DAND1 References
  • Ozaki T, et al. (1995) Overexpression of DAN gene product in normal rat fibroblasts causes a retardation of the entry into the S phase. Cancer Res. 55(4): 895-900.
  • Nakamura Y, et al. (1997) A product of DAN, a novel candidate tumour suppressor gene, is secreted into culture medium and suppresses DNA synthesis. Eur J Cancer. 33(12): 1986-90.
  • Ogita J, et al. (2001) Expression of the Dan gene during chicken embryonic development. Mech Dev. 109(2): 363-5.
  • Kim AS, et al. (2003) Expression of the BMP antagonist Dan during murine forebrain development. Brain Res Dev Brain Res. 145(1): 159-62.
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    Catalog: 10169-RP02-50
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    Datasheet & Documentation

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"