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NAP-2 / PPBP / CXCL7  Protein, Antibody, ELISA Kit, cDNA Clone

Expression host: E. coli  
  • Slide 1
10878-H07E-50
10878-H07E-20
50 µg 
20 µg 
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Expression host: E. coli  
  • Slide 1
50145-M07E-20
50145-M07E-10
20 µg 
10 µg 
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Expression host: E. coli  
  • Slide 1
50145-M07E1-20
50145-M07E1-10
20 µg 
10 µg 
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Expression host: Yeast  
  • Slide 1
80066-R08Y-20
80066-R08Y-100
20 µg 
100 µg 
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Expression host: Human Cells  
  • Slide 1
80066-R01H-20
80066-R01H-10
20 µg 
10 µg 
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Expression host: Human Cells  
  • Slide 1
90132-C04H-20
90132-C04H-10
20 µg 
10 µg 
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Expression host: Yeast  
  • Slide 1
90132-C08Y-20
90132-C08Y-100
20 µg 
100 µg 
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NAP-2 / PPBP / CXCL7 Related Area

NAP-2 / PPBP / CXCL7 Related Pathways

    NAP-2 / PPBP / CXCL7 Summary & Protein Information

    NAP-2 / PPBP / CXCL7 Background

    Gene Summary: The protein encoded by this PPBP gene is a platelet-derived growth factor that belongs to the CXC chemokine family. NAP-2 is a potent chemoattractant and activator of neutrophils. NAP-2 has been shown to stimulate various cellular processes including DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and synthesis of hyaluronic acid and sulfated glycosaminoglycan. NAP-2 also stimulates the formation and secretion of plasminogen activator by synovial cells.
    General information above from NCBI
    Subunit structure: Beta-thromboglobulin is a homotetramer.
    Subcellular location: Secreted.
    Post-translational: Proteolytic removal of residues 1-9 produces the active peptide connective tissue-activating peptide III (CTAP-III) (low-affinity platelet factor IV (LA-PF4)).; Proteolytic removal of residues 1-13 produces the active peptide beta-thromboglobulin, which is released from platelets along with platelet factor 4 and platelet-derived growth factor.; NAP-2(1-66) is produced by proteolytical processing, probably after secretion by leukocytes other than neutrophils. {ECO:0000269|PubMed:9794434}.; NAP-2(73) and NAP-2(74) seem not be produced by proteolytical processing of secreted precursors but are released in an active form from platelets. {ECO:0000269|PubMed:9794434}.
    Sequence similarity: Belongs to the intercrine alpha (chemokine CxC) family. {ECO:0000305}.
    General information above from UniProt

    Pro-platelet basic protein (PPBP) is also known as Chemokine (C-X-C motif) ligand 7 (CXCL7) and nucleosome assembly protein (Nap-2). Nap-2 / PPBP / CXCL7 is released in large amounts from platelets following their activation and is a platelet-derived growth factor that belongs to the CXC chemokine family. This growth factor is a potent chemoattractant and activator of neutrophils. Nap-2 / PPBP / CXCL7 has been shown to stimulate various cellular processes including DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and synthesis of hyaluronic acid and sulfated glycosaminoglycan. It also stimulates the formation and secretion of plasminogen activator by synovial cells. Nap-2 is a ligand for CXCR1 and CXCR2, and Nap-2, Nap-2 (73), Nap-2 (74), Nap-2 (1-66), and most potent Nap-2 (1-63) are chemoattractants and activators for neutrophils.

    Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

    NAP-2 / PPBP / CXCL7 Alternative Name

    NAP-2 / PPBP / CXCL7 Related Studies

  • Walz A, et al. (1989) Effects of the neutrophil-activating peptide NAP-2, platelet basic protein, connective tissue-activating peptide III and platelet factor 4 on human neutrophils. J Exp Med. 170(5):1745-50.
  • Walz A, et al. (1990) Generation of the neutrophil-activating peptide NAP-2 from platelet basic protein or connective tissue-activating peptide III through monocyte proteases. J Exp Med. 171(2): 449-54.
  • Loetscher P, et al. (1994) Both interleukin-8 receptors independently mediate chemotaxis. Jurkat cells transfected with IL-8R1 or IL-8R2 migrate in response to IL-8, GRO alpha and NAP-2. FEBS Lett. 341(2-3): 187-92.
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