CXCL7 Protein, Mouse, Recombinant (aa 49-109, His Tag) Product Information
> 90 % as determined by SDS-PAGE.
Please contact us for more information.
Testing in progress
A DNA sequence encoding the mouse Ppbp (Q9EQI5) (Ile49-Ile109) was expressed with a polyhistidine tag at the N-terminus.
The recombinant mouse Ppbp consists 80 amino acids and predicts a molecular mass of 9 kDa.
Lyophilized from sterile 50 mM Tris, 0.5 M NaCl, 15 % glycerol.
1. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
2. Please contact us
for any concerns or special requirements.
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Stability & Storage
Samples are stable for up to twelve months from date of receipt at -70℃
Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
CXCL7 Protein, Mouse, Recombinant (aa 49-109, His Tag) in SDS-PAGE
CXCL7 Protein, Mouse, Recombinant (aa 49-109, His Tag) Alternative Names
2400003M24Rik Protein, Mouse;AI854500 Protein, Mouse;b-TG1 Protein, Mouse;beta-TG Protein, Mouse;CTAP3 Protein, Mouse;CTAPIII Protein, Mouse;Cxcl7 Protein, Mouse;LA-PF4 Protein, Mouse;LDGF Protein, Mouse;MDGF Protein, Mouse;NAP-2 Protein, Mouse;NAP-2-L1 Protein, Mouse;Scyb7 Protein, Mouse;TGB Protein, Mouse;TGB1 Protein, Mouse;THBGB1 Protein, Mouse
CXCL7 Background Information
Pro-platelet basic protein (PPBP) is also known as Chemokine (C-X-C motif) ligand 7 (CXCL7) and nucleosome assembly protein (Nap-2). Nap-2 / PPBP / CXCL7 is released in large amounts from platelets following their activation and is a platelet-derived growth factor that belongs to the CXC chemokine family. This growth factor is a potent chemoattractant and activator of neutrophils. Nap-2 / PPBP / CXCL7 has been shown to stimulate various cellular processes including DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and synthesis of hyaluronic acid and sulfated glycosaminoglycan. It also stimulates the formation and secretion of plasminogen activator by synovial cells. Nap-2 is a ligand for CXCR1 and CXCR2, and Nap-2, Nap-2 (73), Nap-2 (74), Nap-2 (1-66), and most potent Nap-2 (1-63) are chemoattractants and activators for neutrophils.
Immune Checkpoint Immunotherapy Cancer Immunotherapy Targeted Therapy
pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
Walz A, et al. (1989) Effects of the neutrophil-activating peptide NAP-2, platelet basic protein, connective tissue-activating peptide III and platelet factor 4 on human neutrophils. J Exp Med. 170(5):1745-50. Walz A, et al. (1990) Generation of the neutrophil-activating peptide NAP-2 from platelet basic protein or connective tissue-activating peptide III through monocyte proteases. J Exp Med. 171(2): 449-54. Loetscher P, et al. (1994) Both interleukin-8 receptors independently mediate chemotaxis. Jurkat cells transfected with IL-8R1 or IL-8R2 migrate in response to IL-8, GRO alpha and NAP-2. FEBS Lett. 341(2-3): 187-92.