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> NAALADL1 NAALADL1
NAALADase-like activity unknown. NAALADL1 has no NAAG hydrolyzing activity. NAALADL1 exhibits a dipeptidyl-peptidase IV type activity. In vitro, NAALADL1 cleaves Gly-Pro-AMC.
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NAALADL1 Related Products
NAALADL1 Proteins
- Human NAALADL1 Protein, Recombinant, Cat NO: 11146-H07H
- Mouse NAALADL1 Protein, Recombinant, Cat NO: 50937-M07H
NAALADL1 Antibodies
- Anti-Human NAALADL1 Antibody, Mouse MAb, Cat NO: 11146-MM05
- Anti-Human NAALADL1 Antibody, Cat NO: 11146-MM08
- Anti-Human NAALADL1 Antibody, Rabbit MAb, Cat NO: 11146-R029
- Anti-Human NAALADL1 Antibody,Rabbit PAb, Cat NO: 11146-RP01
- Anti-Human NAALADL1 Antibody,Rabbit PAb (Antigen Affinity Purified), Cat NO: 11146-RP02
NAALADL1 ELISA Pair sets
NAALADL1 cDNA Clones
- Homo sapiens NAALADL1 cDNA Clone(NM_005468.2), Cat NO: HG11146-M
- Mouse NAALADL1 cDNA Clone / ORF Clone, Cat NO: MG50937-G
NAALADL1 Related Areas
Enzyme>>Protease & Regulator>>Metalloprotease & Regulator>>NAALADL1
NAALADL1 Related Pathways
NAALADL1 Alternative Names
NAALADL1, NAALADASEL, I100 [Homo sapiens]
Naaladl1, Naaladasel, Gm964 [Mus musculus]
Summaries for NAALADL1
Human NAALADL1 Protein General Information
| Protein names |
N-acetylated-alpha-linked acidic dipeptidase-like protein, Short name=NAALADase L |
| Sequence length |
740 AA. |
| Catalytic activity |
Release of an unsubstituted, C-terminal glutamyl residue, typically from Ac-Asp-Glu or folylpoly-gamma-glutamates. |
| Sequence similarities: |
NAALADL1 belongs to the peptidase M28 family. M28B subfamily. |
| Cofactor: |
NAALADL1 binds 2 zinc ions per subunit |
| Subunit structure |
Apical cell membrane; Single-pass type II membrane protein. Note: Ileal brush border membrane. |
| Tissue specificity |
NAALADL1 is mainly expressed in the distal small intestine. NAALADL1 is also expressed in the spleen and testis. Weak expression in the brain, locating mainly to the brain stem, amygdala, thalamus and ventral striatum. Isoform 2 and 3 isoform 3 are found in the small intestine and colon. |
| Sequence caution: | The sequence AAB87645.1 differs from that shown. Reason: Frameshift at positions 686 and 693. |
General information above from UniProt
Function for NAALADL1 Protein
UniProtKB:
NAALADase-like activity unknown. NAALADL1 has no NAAG hydrolyzing activity. NAALADL1 exhibits a dipeptidyl-peptidase IV type activity. In vitro, NAALADL1 cleaves Gly-Pro-AMC.
Genatlas:
- NAALADL1 is the regulator in the intestinal absorption of dietary folylpolygammaglutamate
Homology for human NAALADL1
- homolog to rattus I100
- homolog to FOLH1
