Anti-NAALADL1 Antibody

Cat: 11146-RP01
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Anti-NAALADL1 Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-NAALADL1 Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human NAALADL1
Immunogen
Recombinant Human NAALADL1 protein (Catalog#11146-H07H)
Preparation
Produced in rabbits immunized with purified, recombinant Human NAALADL1 (rh NAALADL1; Catalog#11146-H07H; NP_005459.2; Pro 29-Leu 740). Total IgG was purified by Protein A affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-NAALADL1 Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:1000-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-NAALADL1 Antibody Alternative Names
Anti-I100 Antibody;Anti-NAALADASEL Antibody;Anti-NAALADL1 Antibody
NAALADL1 Background Information

N-acetylated-alpha-linked acidic dipeptidase-like protein, also known as NAALADL1, NAALADase L, and Ileal dipeptidylpeptidase, is a Single-pass type I I membrane protein and a member of the peptidase M28 family and M28B subfamily. NAALADase L is mainly expressed in the distal small intestine. It is also expressed in the spleen and testis and Weakly expressed in the brain, locating mainly to the brain stem, amygdala, thalamus and ventral striatum. NAALADase L is a chloride-activated, membrane bound, metallopeptidase that cleaves the endogenous neuropeptide N-acetyl-aspartyl-glutamate (NAAG). NAAG acts as a partial NMDA agonist as well as a full agonist at the presynaptic metabotropic glutamate receptor 3 (mGluR3), where it acts to reduce glutamate release. NAALADase L also exhibits a dipeptidyl-peptidase IV type activity. NAALADase inhibition may be a novel therapeutic approach to reduce or inhibit heightened aggressiveness, and possibly to treat aggressive behavior associated with psychiatric disorders.

Full Name
N-acetylated alpha-linked acidic dipeptidase-like 1
References
  • Stauch BL. 1989, Neurosci Lett. 100 (1-3): 295-300.
  • Shneider BL. et al., 1997, J. Biol. Chem. 272: 31006-15.
  • Pangalos MN. et al., 1999, J. Biol. Chem. 274: 8470-83.
  • Thomas AG. et al., 1999, Brain Res. 843 (1-2): 48-52.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-NAALADL1 Antibody Rabbit Polyclonal ELISA,IHC-P 50937-RP02
    Anti-NAALADL1 Antibody Rabbit Monoclonal IHC-P 50937-R022
    Anti-NAALADL1 Antibody Rabbit Monoclonal ELISA 50937-R005
    Anti-NAALADL1 Antibody Rabbit Monoclonal ELISA 50937-R026
    Anti-NAALADL1 Antibody Rabbit Polyclonal ELISA 50937-RP01
    Anti-NAALADL1 Antibody Mouse Monoclonal ELISA 11146-MM05
    Anti-NAALADL1 Antibody Rabbit Monoclonal WB,ELISA 11146-R029
    Anti-NAALADL1 Antibody Rabbit Polyclonal ELISA 11146-RP02
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