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>Human Cell Expressed
>Rat N-Cadherin / CD325 / CDH2 Protein (His Tag)
|Catalog||Size (Price)||Quantity||In Stock||Operation|
Cadherin 2 Protein Datasheet
N-cadherin / Cadherin 2 / CDH2 Protein Price Inquiry ( Available Sizes )
N-cadherin / Cadherin 2 / CDH2 Protein Product Information
A DNA sequence encoding the rat CDH2(Met1-Ala724) was expressed with a polyhistidine tag at the C-terminus.
|Expression Host:||Human Cells|
N-cadherin / Cadherin 2 / CDH2 Protein QC Testing
|Purity:||> 95 % as determined by SDS-PAGE||SDS-PAGE:
N-cadherin / Cadherin 2 / CDH2 protein
|Endotoxin:||< 1.0 EU per μg of the protein as determined by the LAL method|
|Stability:||Samples are stable for up to twelve months from date of receipt at -70℃|
|Predicted N terminal:||Ser 26|
The recombinant rat CDH2 comprises 710 amino acids and predicts a molecular mass of 78.4 kDa. The apparent molecular mass of the recombinant protein is approximately 44-53 kDa in SDS-PAGE under reducing conditions due to glycosylation.
|Formulation:||Lyophilized from sterile PBS, pH 7.4.
N-cadherin / Cadherin 2 / CDH2 Protein Usage Guide
|Storage:||Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.|
|Reconstitution:||A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.|
N-cadherin / Cadherin 2 / CDH2 Protein Related Products & Topics
|Molecule||Species||Description //For Detailed Info. and Price------CLICK!||Cat. No|
|N-Cadherin/CD325/CDH2||Human||N-Cadherin/CD325/CDH2 Protein, Recombinant||11039-H08H|
|N-Cadherin/CD325/CDH2||Rat||N-cadherin / Cadherin 2 / CDH2 Protein, Recombinant||80275-R08H|
|Molecule||Application||Description //For Detailed Info. and Price------CLICK!||Cat. No|
|Human N-Cadherin/CD325/CDH2||FCM||N-Cadherin / CD325 / CDH2 Antibody||11039-R001|
|Human N-Cadherin/CD325/CDH2||WB, ELISA||N-Cadherin / CD325 / CDH2 Antibody||11039-R014|
|Human N-Cadherin/CD325/CDH2||WB, ELISA||N-Cadherin / CD325 / CDH2 Antibody||11039-R017|
|Human N-Cadherin/CD325/CDH2||WB, ELISA, FCM||N-Cadherin / CD325 / CDH2 Antibody||11039-R020|
N-cadherin / Cadherin 2 / CDH2 Protein Description
Cadherins are calcium dependent cell adhesion proteins, and they preferentially interact with themselves in a homophilic manner in connecting cells. Human cadherin 2, type 1, N-cadherin (neuronal) (NCAD) , also known as CDH2, is a single-pass tranmembrane protein and a cadherin containing 5 cadherin domains. N-cadherin displays a ubiquitous expression pattern but with different expression levels between endocrine cell types. CDH2 (NCAD) has been shown to play an essential role in normal neuronal development, which is implicated in an array of processes including neuronal differentiation and migration, and axon growth and fasciculation. In addition, N-cadherin expression was upregulated in human HSC during activation in culture, and function or expression blocking of N-cadherin promoted apoptosis. During apoptosis, N-cadherin was cleaved into 20-100 kDa fragments. N-cadherin cleavage occurred at a higher level in glioblastoma cells than in non-neoplastic astrocytes.
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