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Rat N-Cadherin / CD325 / CDH2 Protein (His Tag)
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Rat N-Cadherin / CD325 / CDH2 Protein (His Tag) PDF Download

Catalog   Size (Price) Quantity In Stock Operation
80275-R08H  
YES   
 

Protein Production & Purification Service | Recombinant Cytokines & Growth Factors

Cadherin 2 Protein Datasheet

 

N-cadherin / Cadherin 2 / CDH2 Protein Price Inquiry ( Available Sizes )

N-cadherin / Cadherin 2 / CDH2 Protein Product Information

Synonym : CDH2
Protein Construction:

A DNA sequence encoding the rat CDH2(Met1-Ala724) was expressed with a polyhistidine tag at the C-terminus.

Source: Rat
Expression Host: Human Cells

N-cadherin / Cadherin 2 / CDH2 Protein QC Testing

Purity: > 95 % as determined by SDS-PAGE SDS-PAGE:
SDS-PAGE

N-cadherin / Cadherin 2 / CDH2 protein

Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method
Stability: Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal: Ser 26
Molecular Mass:

The recombinant rat CDH2 comprises 710 amino acids and predicts a molecular mass of 78.4 kDa. The apparent molecular mass of  the recombinant protein is approximately 44-53 kDa in SDS-PAGE under reducing conditions due to glycosylation.

Formulation: Lyophilized from sterile PBS, pH 7.4.
  1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
  2. Please contact us for any concerns or special requirements.

N-cadherin / Cadherin 2 / CDH2 Protein Usage Guide

Storage: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

N-cadherin / Cadherin 2 / CDH2 Protein Related Products & Topics

Related Areas:

Neuroscience>>Synaptic Protein>>N-Cadherin/CDH2/CD325

Stem Cell>>Mesenchymal Stem Cell (MSC)>>Mesenchymal Stem Cell Marker>>N-Cadherin/CDH2/CD325

Cancer>>Angiogenesis>>Adhesion Molecules in Angiogenesis>>N-Cadherin/CDH2/CD325

Immunology>>Adhesion Molecule>> Cadherin>>N-Cadherin/CDH2/CD325

Immunology>>Cluster of Differentiation>>N-Cadherin/CDH2/CD325

Proteins:

Molecule Species Description //For Detailed Info. and Price------CLICK! Cat. No
N-Cadherin/CD325/CDH2 Human N-Cadherin/CD325/CDH2 Protein, Recombinant 11039-H08H
N-Cadherin/CD325/CDH2 Rat N-cadherin / Cadherin 2 / CDH2 Protein, Recombinant 80275-R08H

Antibodies:

Molecule Application Description //For Detailed Info. and Price------CLICK! Cat. No
Human N-Cadherin/CD325/CDH2 FCM N-Cadherin / CD325 / CDH2 Antibody 11039-R001
Human N-Cadherin/CD325/CDH2 WB, ELISA N-Cadherin / CD325 / CDH2 Antibody 11039-R014
Human N-Cadherin/CD325/CDH2 WB, ELISA N-Cadherin / CD325 / CDH2 Antibody 11039-R017
Human N-Cadherin/CD325/CDH2 WB, ELISA, FCM N-Cadherin / CD325 / CDH2 Antibody 11039-R020

N-cadherin / Cadherin 2 / CDH2 Protein Description

Cadherins are calcium dependent cell adhesion proteins, and they preferentially interact with themselves in a homophilic manner in connecting cells. Human cadherin 2, type 1, N-cadherin (neuronal) (NCAD) , also known as CDH2, is a single-pass tranmembrane protein and a cadherin containing 5 cadherin domains. N-cadherin displays a ubiquitous expression pattern but with different expression levels between endocrine cell types. CDH2 (NCAD) has been shown to play an essential role in normal neuronal development, which is implicated in an array of processes including neuronal differentiation and migration, and axon growth and fasciculation. In addition, N-cadherin expression was upregulated in human HSC during activation in culture, and function or expression blocking of N-cadherin promoted apoptosis. During apoptosis, N-cadherin was cleaved into 20-100 kDa fragments. N-cadherin cleavage occurred at a higher level in glioblastoma cells than in non-neoplastic astrocytes.

References

  1. LaMora A. et al., 2009, Neuroscience. 159: 1175-84
  2. Chauvet N. et al., 2009, J Endocrinol. 202: 375-87.
  3. Hartland S.N. et al., 2009, Liver Int. 29: 966-78.
  4. Kohutek Z.A. et al., 2009, J Neurosci. 29: 4605-15.
 
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"