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N-Cadherin/CD325/CDH2  Protein, Antibody, ELISA Kit, cDNA Clone

Expression host: Baculovirus-Insect Cells  
11039-H08B-50
11039-H08B-200
50 µg 
200 µg 
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Expression host: Human Cells  
11039-H03H-50
11039-H03H-100
50 µg 
100 µg 
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Description: Active  
Expression host: Human Cells  
11039-H08H-50
11039-H08H-100
50 µg 
100 µg 
Add to Cart
  • Slide 1
Expression host: Human Cells  
50752-MCCH-50
50752-MCCH-100
50 µg 
100 µg 
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  • Slide 1

N-Cadherin/CD325/CDH2 Related Area

N-Cadherin/CD325/CDH2 Related Pathways

N-Cadherin/CD325/CDH2 Related Protein, Antibody, cDNA Gene, and ELISA Kits

N-Cadherin/CD325/CDH2 Summary & Protein Information

N-Cadherin/CD325/CDH2 Background

Gene Summary: This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. The protein functions during gastrulation and is required for establishment of left-right asymmetry. At certain central nervous system synapses, presynaptic to postsynaptic adhesion is mediated at least in part by this gene product.
General information above from NCBI
Subunit structure: Interacts with CDCP1. Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN. Interacts with PCDH8; this complex may also include TAOK2. The interaction with PCDH8 may lead to internalization through TAOK2/p38 MAPK pathway (By similarity). {ECO:0000250}.
Domain: Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain. Calcium-binding sites are occupied sequentially in the order of site 3, then site 2 and site 1 (By similarity). {ECO:0000250}.
Subcellular location: Cell membrane; Single-pass type I membrane protein.
Post-translational: Cleaved by MMP24. Ectodomain cleavage leads to the generation of a soluble 90 kDa amino-terminal soluble fragment and a 45 kDa membrane-bound carboxy-terminal fragment 1 (CTF1), which is further cleaved by gamma-secretase into a 35 kDa. Cleavage in neural stem cells by MMP24 affects CDH2-mediated anchorage of neural stem cells to ependymocytes in the adult subependymal zone, leading to modulate neural stem cell quiescence (By similarity). {ECO:0000250}.
Sequence similarity: Contains 5 cadherin domains. {ECO:0000255|PROSITE-ProRule:PRU00043}.
General information above from UniProt

Cadherins are calcium dependent cell adhesion proteins, and they preferentially interact with themselves in a homophilic manner in connecting cells. Cadherin 2 (CDH2), also known as N-Cadherin (neuronal) (NCAD), is a single-pass tranmembrane protein and a cadherin containing 5 cadherin domains. N-Cadherin displays a ubiquitous expression pattern but with different expression levels between endocrine cell types. CDH2 (NCAD) has been shown to play an essential role in normal neuronal development, which is implicated in an array of processes including neuronal differentiation and migration, and axon growth and fasciculation. In addition, N-Cadherin expression was upregulated in human HSC during activation in culture, and function or expression blocking of N-Cadherin promoted apoptosis. During apoptosis, N-Cadherin was cleaved into 20-100 kDa fragments. It may provide a novel target for therapies that are directed toward intimal proliferative disorders, including restenosis and vascular bypass graft failure. N-Cadherin is associated with tumor aggressiveness and metastatic potential and may contribute to tumor progression.

N-Cadherin/CD325/CDH2 Alternative Name

CDHN,NCAD,CD325,CDw325, [homo-sapiens]
cadherin 2,CD325,CDH2,CDHN,CDw325,NCAD,N-cadherin,N-cadherin 1,neural cadherin, [human]
cadherin-2,Cdh2,CDHN,Ncad,N-cadherin,neural cadherin,OTTMUSP00000017505, [mouse]
CDHN,Ncad,N-cadherin, [mus-musculus]

N-Cadherin/CD325/CDH2 Related Studies

  • Jones M, et al. (2002) N-cadherin upregulation and function in response of smooth muscle cells to arterial injury. Arterioscler Thromb Vasc Biol. 22(12): 1972-7.
  • Nagi C, et al. (2005) N-cadherin expression in breast cancer: correlation with an aggressive histologic variant--invasive micropapillary carcinoma. Breast Cancer Res Treat. 94(3): 225-35.
  • Schrick C, et al. (2007) N-cadherin regulates cytoskeletally associated IQGAP1/ERK signaling and memory formation. Neuron. 55(5): 786-98.
  • Li K, et al. (2010) Downregulation of N-cadherin expression inhibits invasiveness, arrests cell cycle and induces cell apoptosis in esophageal squamous cell carcinoma. Cancer Invest. 28(5): 479-86.
  • Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"