N-Cadherin Protein & Antibody (CD325, CDH2)

Neuronal-cadherin (Cluster of Differentiation 325, Cadherin 2)

N-Cadherin Products

N-Cadherin Protein, Recombinant

Molecule	Species	Description	Cat. No
N-Cadherin/CD325/CDH2	Human	N-Cadherin/CD325/CDH2 Protein, Recombinant	11039-H08H

N-Cadherin Antibody

Molecule	Application	Description	Cat. No
Human N-Cadherin/CD325/CDH2	FCM	N-Cadherin / CD325 / CDH2 Antibody	11039-R001
Human N-Cadherin/CD325/CDH2	WB, ELISA	N-Cadherin / CD325 / CDH2 Antibody	11039-R014
Human N-Cadherin/CD325/CDH2	WB, ELISA	N-Cadherin / CD325 / CDH2 Antibody	11039-R017
Human N-Cadherin/CD325/CDH2	WB, ELISA, FCM	N-Cadherin / CD325 / CDH2 Antibody	11039-R020

N-Cadherin cDNA Clone

Molecule	Species	Description	Cat. No
N-Cadherin/CD325/CDH2	Human	Homo sapiens N-Cadherin/CD325/CDH2 cDNA Clone(NM_001792.3)	HG11039-M
N-Cadherin/CD325/CDH2	Mouse	N-Cadherin/CD325/CDH2 cDNA Clone / ORF Clone	MG50752-G
N-Cadherin/CD325/CDH2	Rat	CDH2 cDNA Clone / ORF Clone	RG80275-G

N-Cadherin Alternative Names

N-cadherin, CD325, CDH2, N-cadherin 1, neural cadherin, neural-cadherin, cadherin 2, cadherin-2, CDw325, CDHN, NCAD [Homo sapiens]

N-cadherin, Cdh2, neural cadherin, cadherin-2, Ncad, CDHN, OTTMUSP00000017505 [Mus musculus]

N-Cadherin Related Areas

Neuroscience>>Synaptic Protein>>N-Cadherin/CDH2/CD325

Stem Cell>>Mesenchymal Stem Cell (MSC)>>Mesenchymal Stem Cell Marker>>N-Cadherin/CDH2/CD325

Cancer>>Angiogenesis>>Adhesion Molecules in Angiogenesis>>N-Cadherin/CDH2/CD325

Immunology>>Adhesion Molecule>> Cadherin>>N-Cadherin/CDH2/CD325

Immunology>>Cluster of Differentiation>>N-Cadherin/CDH2/CD325

N-Cadherin Related Products

Protein Products

Molecule	Species	Description //For Detailed Info. and Price------CLICK!
E-Cadherin/CDH1/CD324	Human	E-Cadherin/CDH1 Protein, Recombinant
E-Cadherin/CDH1	Mouse	E-Cadherin/CDH1 Protein, Recombinant
R-Cadherin/CDH4	Mouse	R-Cadherin/CDH4 Protein, Recombinant
Cadherin-6/K-Cadherin/CDH6	Human	Cadherin-6/K-Cadherin/CDH6 Protein, Recombinant
Cadherin-8/CDH8	Human	Cadherin-8/CDH8 Protein, Recombinant
Cadherin-12/CDH12	Human	Cadherin-12/CDH12 Protein, Recombinant
VE-Cadherin/CD144/CDH5	Human	VE-Cadherin/CD114/Fc Protein, Recombinant
VE-Cadherin/CD144/CDH5	Mouse	VE-Cadherin/CD114 Protein, Recombinant
KSP-Cadherin/Cadherin-16/CDH16	Human	KSP-Cadherin/Cadherin-16/CDH16 Protein, Recombinant
Cadherin-17/LI-cadherin	Human	Cadherin-17/LI-cadherin Protein, Recombinant

Antibody Products

Molecule	Applications	Description //For Detailed Info. and Price------CLICK!
Human E-Cadherin/CDH1/CD324	WB, ELISA	Mouse Monoclonal Antibody
Human E-Cadherin/CDH1/CD324	ELISA	Mouse Monoclonal Antibody
Human E-Cadherin/CDH1/CD324	WB, ELISA	Rabbit Polyclonal Antibody
Human E-Cadherin/CDH1/CD324	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)
Human R-Cadherin/CDH4	WB, ELISA	R-Cadherin/CDH4 Antibody, Rabbit PAb
Human R-Cadherin/CDH4	WB, ELISA	R-Cadherin/CDH4 Antibody, Rabbit PAb (Antigen Affinity Purified)
Mouse VE-Cadherin/CD144/CDH5	WB, ELISA	Rabbit Polyclonal Antibody

cDNA Clone Products

Molecule	Species	Description //For Detailed Info. and Price------CLICK!
E-Cadherin/CDH1/CD324	Human	Homo sapiens E-Cadherin/CDH1 cDNA Clone(NM_004360.3)
N-Cadherin/CD325/CDH2	Human	Homo sapiens N-Cadherin/CD325/CDH2 cDNA Clone(NM_001792.3)
P-Cadherin/CDH3	Human	Homo sapiens P-Cadherin/CDH3 cDNA Clone(NM_001793.4)
Cadherin-6/K-Cadherin/CDH6	Human	Homo sapiens Cadherin-6/K-Cadherin/CDH6 cDNA Clone(NM_004932.2)
Cadherin-8/CDH8	Human	Homo sapiens Cadherin-8/CDH8 cDNA Clone(NM_001796.2)
Cadherin-11/CDH11	Human	Homo sapiens Cadherin-11/CDH11 cDNA Clone(NM_001797.2)
Cadherin-12/CDH12	Human	Homo sapiens Cadherin-12/CDH12 cDNA Clone(NM_004061.3)
KSP-Cadherin/CDH16	Human	Homo sapiens Cadherin-16/CDH16 cDNA Clone(NM_004062.2)
Cadherin-17/LI-cadherin	Human	Homo sapiens Cadherin-17/LI-cadherin/CDH17 cDNA Clone
VE-Cadherin/CD144/CDH5	Human	Homo sapiens VE-Cadherin/CD114 cDNA Clone(NM_001795.3)
VE-Cadherin/CD144/CDH5	Mouse	Mus musculus VE-Cadherin/CD114/CDH5 cDNA Clone

N-Cadherin Background

Cadherins are calcium dependent cell adhesion proteins, and they preferentially interact with themselves in a homophilic manner in connecting cells. Cadherin 2 (CDH2), also known as N-Cadherin (neuronal) (NCAD), is a single-pass tranmembrane protein and a cadherin containing 5 cadherin domains. N-Cadherin displays a ubiquitous expression pattern but with different expression levels between endocrine cell types. CDH2 (NCAD) has been shown to play an essential role in normal neuronal development, which is implicated in an array of processes including neuronal differentiation and migration, and axon growth and fasciculation. In addition, N-Cadherin expression was upregulated in human HSC during activation in culture, and function or expression blocking of N-Cadherin promoted apoptosis. During apoptosis, N-Cadherin was cleaved into 20-100 kDa fragments. It may provide a novel target for therapies that are directed toward intimal proliferative disorders, including restenosis and vascular bypass graft failure. N-Cadherin is associated with tumor aggressiveness and metastatic potential and may contribute to tumor progression.

N-Cadherin Related Studies

1. Jones M, et al. (2002) N-cadherin upregulation and function in response of smooth muscle cells to arterial injury. Arterioscler Thromb Vasc Biol. 22(12): 1972-7.
2. Nagi C, et al. (2005) N-cadherin expression in breast cancer: correlation with an aggressive histologic variant--invasive micropapillary carcinoma. Breast Cancer Res Treat. 94(3): 225-35.
3. Schrick C, et al. (2007) N-cadherin regulates cytoskeletally associated IQGAP1/ERK signaling and memory formation. Neuron. 55(5): 786-98.
4. Li K, et al. (2010) Downregulation of N-cadherin expression inhibits invasiveness, arrests cell cycle and induces cell apoptosis in esophageal squamous cell carcinoma. Cancer Invest. 28(5): 479-86.