**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********
Anti-CDH2 rabbit monoclonal antibody at 1:500 dilution
Lane A: Hela Whole Cell LysateLysates/proteins at 30 μg per lane.
Goat Anti-Rabbit IgG H&L (Dylight800) at 1/10000 dilution.Developed using the Odyssey technique.
Performed under reducing conditions.Predicted band size:99 kDa
Observed band size:130 kDa
Cadherins are calcium dependent cell adhesion proteins, and they preferentially interact with themselves in a homophilic manner in connecting cells. Cadherin 2 (CDH2), also known as N-Cadherin (neuronal) (NCAD), is a single-pass tranmembrane protein and a cadherin containing 5 cadherin domains. N-Cadherin displays a ubiquitous expression pattern but with different expression levels between endocrine cell types. CDH2 (NCAD) has been shown to play an essential role in normal neuronal development, which is implicated in an array of processes including neuronal differentiation and migration, and axon growth and fasciculation. In addition, N-Cadherin expression was upregulated in human HSC during activation in culture, and function or expression blocking of N-Cadherin promoted apoptosis. During apoptosis, N-Cadherin was cleaved into 20-100 kDa fragments. It may provide a novel target for therapies that are directed toward intimal proliferative disorders, including restenosis and vascular bypass graft failure. N-Cadherin is associated with tumor aggressiveness and metastatic potential and may contribute to tumor progression.
|Product Description||Host||Clonality||Application||Catalog# (PDF)|
|Anti-N Cadherin Antibody (FITC)||Rabbit||Monoclonal||FCM||11039-R020-F|
|Anti-N Cadherin Antibody (PE)||Rabbit||Monoclonal||FCM||11039-R020-P|
|Anti-N Cadherin Antibody (APC)||Rabbit||Monoclonal||FCM||11039-R001-A|
|Anti-N Cadherin Antibody||Rabbit||Monoclonal||ELISA,ICC/IF,IF||11039-R017|
|Anti-N Cadherin Antibody||Rabbit||Monoclonal||ELISA,ICC/IF,IF||11039-R014|
|Anti-N Cadherin Antibody||Rabbit||Monoclonal||ELISA,FCM||11039-R001|
|Anti-N Cadherin Antibody (PE)||Rabbit||Monoclonal||FCM||11039-R001-P|
|Anti-N Cadherin Antibody (APC)||Rabbit||Monoclonal||FCM||11039-R020-A|
|Anti-N Cadherin Antibody||Rabbit||Polyclonal||ELISA||11039-T16|
|Anti-N Cadherin Antibody||Rabbit||Polyclonal||ELISA||11039-RP01|