CD137 cDNA ORF Clone, Mouse, N-Myc tag

Cat: MG50811-NM
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CD137 cDNA ORF Clone, Mouse, N-Myc tag General Information
Gene
Species
Mouse
NCBI Ref Seq
RefSeq ORF Size
636 bp
Sequence Description
Identical with the Gene Bank Ref. ID sequence.
Description
Full length Clone DNA of Mouse tumor necrosis factor receptor superfamily, member 9, transcript variant 2 with N terminal Myc tag.
Plasmid
Promoter
Enhanced CMV promoter
Vector
pCMV3-SP-N-Myc
Restriction Sites
KpnI + NotI (6kb + 0.66kb)
Tag Sequence
Myc Tag Sequence: GAGCAGAAACTCATCTCAGAAGAGGATCTG
Sequencing Primers
T7( 5' TAATACGACTCACTATAGGG 3' )
BGH( 5' TAGAAGGCACAGTCGAGG 3' )
Quality Control
The plasmid is confirmed by full-length sequencing.
Screening
Antibiotic in E.coli
Kanamycin
Antibiotic in Mammalian cell
Hygromycin
Application
Stable or Transient mammalian expression
Storage & Shipping
Shipping
Each tube contains lyophilized plasmid.
Storage
The lyophilized plasmid can be stored at ambient temperature for three months.
CD137 cDNA ORF Neucleotide Sequence and Amino Acid Sequence Information

**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**

CD137 cDNA ORF Clone, Mouse, N-Myc tag Validated Images
Human IL1RL1/IL‑1 R4 Gene Plasmid Map 5660
CD137 cDNA ORF Clone, Mouse, N-Myc tag Alternative Names
4-1BB cDNA ORF Clone, Mouse;A930040I11Rik cDNA ORF Clone, Mouse;AA408498 cDNA ORF Clone, Mouse;AI325004 cDNA ORF Clone, Mouse;Cd137 cDNA ORF Clone, Mouse;CDw137 cDNA ORF Clone, Mouse;ILA cDNA ORF Clone, Mouse;Ly63 cDNA ORF Clone, Mouse
CD137 Background Information

CD137 (also known as 4-1BB) is a surface co-stimulatory glycoprotein originally described as present on activated T lymphocytes, which belongs to the tumor necrosis factor (TNF) receptor superfamily. It is expressed mainly on activated CD4+ and CD8+ T cells, and binds to a high-affinity ligand (4-1BBL) expressed on several antigen-presenting cells such as macrophages and activated B cells. Upon ligand binding, 4-1BB is associated with the tumor necrosis factor receptor–associated factors (TRAFs), the adaptor protein which mediates downstream signaling events including the activation of NF-kappaB and cytokine production. 4-1BB signaling either by binding to 4-1BBL or by antibody ligation delivers signals for T-cell activation and growth, as well as monocyte proliferation and B-cell survival, and plays an important role in the amplification of T cell-mediated immune responses. In addition, CD137 and CD137L are expressed in different human primary tumor tissues, suggesting that they may influence the progression of tumors. Crosslinking of CD137 on activated T cells has shown promise in enhancing anti-tumor immune responses in murine models, and agonistic anti-CD137 antibodies are currently being tested in phase I clinical trials.

Immune Checkpoint
Immune Checkpoint Detection: Antibodies   Immune Checkpoint Detection: ELISA Antibodies
Immune Checkpoint Proteins
Immune Checkpoint Targets   Co-stimulatory Immune Checkpoint Targets

Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Full Name
tumor necrosis factor receptor superfamily, member 9
Research Areas
References
  • Sica G, et al. (1999) Biochemical and immunological characteristics of 4-1BB (CD137) receptor and ligand and potential applications in cancer therapy. Arch Immunol Ther Exp (Warsz). 47(5): 275-9.
  • Nam KO, et al. (2005) The therapeutic potential of 4-1BB (CD137) in cancer. Curr Cancer Drug Targets. 5(5): 357-63.
  • Wang Q, et al. (2008) Analysis of CD137 and CD137L expression in human primary tumor tissues. Croat Med J. 49(2): 192-200.
  • Melero I, et al. (2008) Multi-layered action mechanisms of CD137 (4-1BB)-targeted immunotherapies. Trends Pharmacol Sci. 29(8): 383-90.
  • Thum E, et al. (2009) CD137, implications in immunity and potential for therapy. Front Biosci. 14: 4173-88.
  • CD137 cDNA ORF Clone, Canine, Related Products

    Product Name Catalog#(PDF)
    CD137 cDNA ORF Clone in Cloning Vector, Canine DG70095-G
    CD137 cDNA ORF Clone, Canine, untagged DG70095-UT
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    CD137 Lentiviral cDNA ORF Clone, Canine, C-GFPSpark® tag DG70095-ACGLN
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    CD137 cDNA ORF Clone, Canine, N-His tag DG70095-NH
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    CD137 cDNA ORF Clone, Rhesus, Related Products

    Product Name Catalog#(PDF)
    CD137 cDNA ORF Clone in Cloning Vector, Rhesus CG90847-G
    CD137 cDNA ORF Clone, Rhesus, untagged CG90847-UT
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    CD137 Lentiviral cDNA ORF Clone, Rhesus, C-GFPSpark® tag CG90847-ACGLN
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    CD137 cDNA ORF Clone, Rhesus, C-DDK (Flag®) tag CG90847-CF
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    CD137 cDNA ORF Clone, Rhesus, C-His tag CG90847-CH
    CD137 cDNA ORF Clone, Rhesus, N-His tag CG90847-NH
    CD137 cDNA ORF Clone, Rhesus, C-HA tag CG90847-CY
    CD137 cDNA ORF Clone, Rhesus, N-HA tag CG90847-NY
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    CD137 cDNA ORF Clone, Rhesus, N-Myc tag CG90847-NM

    CD137 cDNA ORF Clone, Rat, Related Products

    Product Name Catalog#(PDF)
    CD137 cDNA ORF Clone in Cloning Vector, Rat RG80176-G
    CD137 cDNA ORF Clone, Rat, untagged RG80176-UT
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    CD137 Lentiviral cDNA ORF Clone, Rat, C-GFPSpark® tag RG80176-ACGLN
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    CD137 cDNA ORF Clone, Rat, C-DDK (Flag®) tag RG80176-CF
    CD137 cDNA ORF Clone, Rat, N-DDK (Flag®) tag RG80176-NF
    CD137 cDNA ORF Clone, Rat, C-His tag RG80176-CH
    CD137 cDNA ORF Clone, Rat, N-His tag RG80176-NH
    CD137 cDNA ORF Clone, Rat, C-HA tag RG80176-CY
    CD137 cDNA ORF Clone, Rat, N-HA tag RG80176-NY
    CD137 cDNA ORF Clone, Rat, C-Myc tag RG80176-CM
    CD137 cDNA ORF Clone, Rat, N-Myc tag RG80176-NM
    CD137 qPCR Primer Pairs, Rat RP300169

    CD137 cDNA ORF Clone, Mouse, Related Products

    Product Name Catalog#(PDF)
    CD137 cDNA ORF Clone in Cloning Vector, Mouse MG50811-G
    CD137 cDNA ORF Clone, Mouse, untagged MG50811-UT
    CD137 Lentiviral cDNA ORF Clone, Mouse, C-GFPSpark® tag MG50811-ACGLN
    CD137 cDNA ORF Clone, Mouse, C-GFPSpark® tag MG50811-ACG
    CD137 cDNA ORF Clone, Mouse, C-OFPSpark® tag MG50811-ACR
    CD137 cDNA ORF Clone, Mouse, C-DDK (Flag®) tag MG50811-CF
    CD137 cDNA ORF Clone, Mouse, N-DDK (Flag®) tag MG50811-NF
    CD137 cDNA ORF Clone, Mouse, C-His tag MG50811-CH
    CD137 cDNA ORF Clone, Mouse, N-His tag MG50811-NH
    CD137 cDNA ORF Clone, Mouse, C-HA tag MG50811-CY
    CD137 cDNA ORF Clone, Mouse, N-HA tag MG50811-NY
    CD137 cDNA ORF Clone, Mouse, C-Myc tag MG50811-CM
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    CD137 cDNA ORF Clone, Human, Related Products

    Product Name Catalog#(PDF)
    CD137 cDNA ORF Clone in Cloning Vector, Human HG10041-M
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    CD137 cDNA ORF Clone, Human, C-GFPSpark® tag HG10041-ACG
    CD137 Lentiviral cDNA ORF Clone, Human, C-GFPSpark® tag HG10041-ACGLN
    CD137 cDNA ORF Clone, Human, C-OFPSpark® tag HG10041-ACR
    CD137 cDNA ORF Clone, Human, C-DDK (Flag®) tag HG10041-CF
    CD137 cDNA ORF Clone, Human, N-DDK (Flag®) tag HG10041-NF
    CD137 cDNA ORF Clone, Human, C-His tag HG10041-CH
    CD137 cDNA ORF Clone, Human, N-His tag HG10041-NH
    CD137 cDNA ORF Clone, Human, C-HA tag HG10041-CY
    CD137 cDNA ORF Clone, Human, N-HA tag HG10041-NY
    CD137 cDNA ORF Clone, Human, C-Myc tag HG10041-CM
    CD137 cDNA ORF Clone, Human, N-Myc tag HG10041-NM
    CD137 qPCR Primer Pairs, Human HP100134
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