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mouse RTN4R qPCR primer pairs

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    Mouse RTN4R qPCR Product Information
    NCBI RefSeq:
    Gene Synonym:NgR, NOGOR
    PCR_SIZE (bp):
    QPCR Primer Description:Verified forward and reverse primers for analyzing the quantitative expression of gene
    Quality Control:The primer mix has been verified to generate satisfactory qPCR data on Roche LightCycler480
    Shipping_carrier:1 vial of lyophilized qPCR primer mix (1 nmol each primer, sufficient for 200 numbers of 25 μl reactions) is shipped at ambiente temperatura.
    Storage:
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    Sino biological qEASY qPCR primer pairs are used for SYBR Green-based real-time RT-PCR, The primers are designed by using SBI's proprietary primer design algorithm. Our primer collection covers the entire human genomes. It can be widely applied in the quantitative analysis of gene expression.

    Unique Primer Design

    To avoid genomic DNA amplification, at least one primer is designed crosses the junction of exons according to the conserved region of a specific gene with all variants.

    Strict Validation Process

    Confirmed in positive organizations; screened the primer with high specificity and high sensitivity.

    Uniform PCR conditions, Saving time and cost

    ~100% amplification curve, ensuring the accuracy of the RNA quantitative

    Nogo Receptor Background

    Reticulon 4 receptor (RTN4R), also known as Nogo-66 Receptor (NgR), is a glycosylphosphoinositol (GPI)-anchored protein that belongs to the Nogo recptor family including three members. Mouse RTN4R cDNA contains 10 LRP (Leucine-rich) repeats. RTN4R is expressed predominantly in neurons and their axons in the central nervous systems (CNS). As a receptor for myelin-derived proteins Nogo, myelin-associated glycoprotein (MAG), and myelin oligodendrocyte glycoprotein (OMG), RTN4R mediates axonal growth inhibition and may play a role in regulating axonal regeneration and plasticity in the adult CNS. It has been shown that RTN4R performs its inhibitory actions by interacting with the p75 neurotrophin receptor (p75NTR), a TNFRSF member also known for modulating the activities of the Trk family and for inducing apoptosis in neurons and oligodendrocytes. RTN4R may be proposed as a potential drug target for treatment of various neurological conditions such as spinal cord injury, CNS lesions, peripheral nerve injury, stroke and Alzheimer's disease (AD). Additionally, RTN4R may play a role in regulating the function of the gap junctions.

    Mouse Nogo Receptor References

    1. Wang, X. et al., 2006, Ann Neurol. 60(5): 540-549.      

    2. Wang, Y.Z. et al., 2006, Neuroreport.17(6):605-609.       

    3. Zhu, H.Y. et al., 2007, Hum Pathol. 38(3): 426-434.           

    4. David, S. et al., 2008, Trends Neurosci. 31(5): 221-226.       

    5. Jiang, W. et al., 2009, Transl Res. 154(1): 40-48.      

    6. Zhang, L. et al., 2009, J Neurosci, 9(19): 6348-6352.

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    Catalog: MP200136
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