methionyl aminopeptidase 2 cDNA ORF Clone, Mouse, C-HA tag

Cat: MG50528-CY
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methionyl aminopeptidase 2 cDNA ORF Clone, Mouse, C-HA tag General Information
Gene
Species
Mouse
NCBI Ref Seq
RefSeq ORF Size
1437 bp
Description
Full length Clone DNA of Mouse methionine aminopeptidase 2 with C terminal HA tag.
Plasmid
Promoter
Enhanced CMV promoter
Vector
pCMV3-C-HA
Tag Sequence
HA Tag Sequence: TATCCTTACGACGTGCCTGACTACGCC
Sequencing Primers
T7( 5' TAATACGACTCACTATAGGG 3' )
BGH( 5' TAGAAGGCACAGTCGAGG 3' )
Quality Control
The plasmid is confirmed by full-length sequencing.
Screening
Antibiotic in E.coli
Kanamycin
Antibiotic in Mammalian cell
Hygromycin
Application
Stable or Transient mammalian expression
Storage & Shipping
Shipping
Each tube contains lyophilized plasmid.
Storage
The lyophilized plasmid can be stored at ambient temperature for three months.

**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**

methionyl aminopeptidase 2 cDNA ORF Clone, Mouse, C-HA tag Alternative Names
4930584B20Rik cDNA ORF Clone, Mouse;A930035J23Rik cDNA ORF Clone, Mouse;AI047573 cDNA ORF Clone, Mouse;AL024412 cDNA ORF Clone, Mouse;Amp2 cDNA ORF Clone, Mouse;AU014659 cDNA ORF Clone, Mouse;Mnpep cDNA ORF Clone, Mouse;p67 cDNA ORF Clone, Mouse;p67eIF2 cDNA ORF Clone, Mouse
methionyl aminopeptidase 2 Background Information

METAP2 (Methionine aminopeptidase 2), also known as MAP2 is a a protein which belongs to the peptidase M24A family. MAP2 binds 2 cobalt or manganese ions and contains approximately 12 O-linked N-acetylglucosamine (GlcNAc) residues. It is found in all organisms and is especially important because of its critical role in tissue repair and protein degradation. The catalytic activity of human MAP2 toward Met-Val peptides is consistently two orders of magnitude higher than that of METAP1, suggesting that it is responsible for processing proteins containing N-terminal Met-Val and Met-Thr sequences in vivo. This protein functions both by protecting the alpha subunit of eukaryotic initiation factor 2 from inhibitory phosphorylation and by removing the amino-terminal methionine residue from nascent protein. MAP2 protects eukaryotic initiation factor EIF2S1 from translation-inhibiting phosphorylation by inhibitory kinases such as EIF2AK2/PKR and EIF2AK1/HCR. It also plays a critical role in the regulation of protein synthesis.

Full Name
methionyl aminopeptidase 2
Research Areas
References
  • Bennett, et al. (1997) EPR Studies on the Mono- and Dicobalt (II)-Substituted Forms of the Aminopeptidase from Aeromonas proteolytica. Insight into the Catalytic Mechanism of Dinuclear Hydrolases. J Am Chem Soc. 119:1923-33.
  • Johansson, et al. (2008) Dicobalt II-II, II-III, and III-III Complexes as Spectroscopic Models for Dicobalt Enzyme Active Sites. Inorg Chem. 47:5079-92.
  • Bradshaw, et al. (2002) Aminopeptidases and angiogenesis. Essays Biochem. 38: 5-78.
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    methionyl aminopeptidase 2 cDNA ORF Clone, Mouse, Related Products

    Product Name Catalog#(PDF)
    methionyl aminopeptidase 2 cDNA ORF Clone in Cloning Vector, Mouse MG50528-M
    methionyl aminopeptidase 2 cDNA ORF Clone, Mouse, untagged MG50528-UT
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    methionyl aminopeptidase 2 cDNA ORF Clone, Mouse, C-GFPSpark® tag MG50528-ACG
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    methionyl aminopeptidase 2 cDNA ORF Clone, Mouse, C-DDK (Flag®) tag MG50528-CF
    methionyl aminopeptidase 2 cDNA ORF Clone, Mouse, N-DDK (Flag®) tag MG50528-NF
    methionyl aminopeptidase 2 cDNA ORF Clone, Mouse, C-His tag MG50528-CH
    methionyl aminopeptidase 2 cDNA ORF Clone, Mouse, N-His tag MG50528-NH
    methionyl aminopeptidase 2 cDNA ORF Clone, Mouse, N-HA tag MG50528-NY
    methionyl aminopeptidase 2 cDNA ORF Clone, Mouse, C-Myc tag MG50528-CM
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    methionyl aminopeptidase 2 cDNA ORF Clone, Human, Related Products

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