CXCL1 qPCR Primer Pairs, Mouse

Cat: MP200180
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CXCL1 qPCR Primer Pairs, Mouse General Information
Target Details
Species:
Mouse
Product Details
Oligo-Type:
qPCR Primers
Component:
1 vial of lyophilized qPCR primer mix (1 nmol each primer, sufficient for 200 numbers of 25 μl reactions).
QPCR Primer Description:
Verified forward and reverse primers for analyzing the quantitative expression of gene.
Application & Quality
Application:
SYBR® Green-based quantitative real-time PCR (qPCR).
Quality Control:
The primer mix has been verified to generate satisfactory qPCR data on Roche Applied-science LightCycler® 480 Ⅱ.
Storage & Shipping
Shipping:
Lyophilized qPCR primer mix is shipped at ambiente temperatura
Storage:
The lyophilized product is stable for one year from date of receipt when stored at -20℃. The suspended product is stable for six months from date of receipt when stored at -20℃.

***Sino biological qEASY qPCR primer pairs are used for SYBR Green-based real-time RT-PCR, The primers are designed by using SBI's proprietary primer design algorithm. Our primer collection covers the entire human genomes. It can be widely applied in the quantitative analysis of gene expression.***

Features and Advantages
Unique Primer Design
To avoid genomic DNA amplification, at least one primer is designed crosses the junction of exons according to the conserved region of a specific gene with all variants.
Strict Validation Process
Confirmed in positive organizations; screened the primer with high specificity and high sensitivity.
Uniform PCR conditions, Saving time and cost
~100% amplification curve, ensuring the accuracy of the RNA quantitative
CXCL1 qPCR Primer Pairs, Mouse Alternative Names
Fsp qPCR Primer Pairs, Mouse;gro qPCR Primer Pairs, Mouse;Gro1 qPCR Primer Pairs, Mouse;KC qPCR Primer Pairs, Mouse;Mgsa qPCR Primer Pairs, Mouse;N51 qPCR Primer Pairs, Mouse;Scyb1 qPCR Primer Pairs, Mouse
CXCL1 Background Information

The Chemokine (C-X-C motif) Ligand 1, CXCL1, is a small cytokine belonging to the CXC chemokine family that was previously called GRO1 oncogene, GRO?, KC, Neutrophil-activating protein 3 (NAP-3) and melanoma growth stimulating activity, alpha (MSGA-a). CXCL1 already known to be important in osteoarthritis (OA), as a novel target gene of transcription factor AP-2? in chondrocytes and support the important role of AP-2? in cartilage. CXCL1 is a potent neutrophil chemoattractant with recognized roles in angiogenesis and inflammation. CXCL1 is a novel immediate PTH/PTHrP-responsive gene. CXCL1 may act as a chemoattractant for osteoclast precursors. CXCL1 may also have important pro-nociceptive effects via its direct actions on sensory neurons, and may induce long-term changes that involve protein synthesis. CXCL1 plays a critical nonredundant role in the development of experimental Lyme arthritis and carditis via CXCR2-mediated recruitment of neutrophils into the site of infection. CXCL1 functions through CXCR2 to transactivate the EGFR by proteolytic cleavage of HB-EGF, leading to activation of MAPK signalling and increased proliferation of epithelial ovarian cancer (EOC) cells. It might limit tumor growth by reinforcing senescence early in tumorigenesis. Thus, CXCL1 plays a role in spinal cord development by inhibiting the migration of oligodendrocyte precursors and is involved in the processes of angiogenesis, inflammation, wound healing, and tumorigenesis.

Full Name
chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
References
  • Wang JG, et al. (2008) The chemokine CXCL1/growth related oncogene increases sodium currents and neuronal excitability in small diameter sensory neurons. Mol Pain. 4: 38.
  • Acosta JC, et al. (2009) A role for CXCR2 in senescence, but what about in cancer? Cancer Res. 69(6): 2167-70.
  • Onan D, et al. (2009) The chemokine Cxcl1 is a novel target gene of parathyroid hormone (PTH)/PTH-related protein in committed osteoblasts. Endocrinology. 150(5): 2244-53.
  • Ritzman AM, et al. (2010) The chemokine receptor CXCR2 ligand KC (CXCL1) mediates neutrophil recruitment and is critical for development of experimental Lyme arthritis and carditis. Infect Immun. 78(11): 4593-600.
  • Bolitho C, et al. (2010) The chemokine CXCL1 induces proliferation in epithelial ovarian cancer cells by transactivation of the epidermal growth factor receptor. Endocr Relat Cancer. 17(4): 929-40.
  • Wenke AK, et al. (2011) The transcription factor AP-2? regulates CXCL1 during cartilage development and in osteoarthritis. Osteoarthritis Cartilage. 19(2): 206-12.
  • CXCL1 qPCR Primer Pairs, Rat, Related Products

    Product Name Catalog#(PDF)
    CXCL1 cDNA ORF Clone in Cloning Vector, Rat RG80039-M
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    CXCL1 cDNA ORF Clone, Rat, C-His tag RG80039-CH
    CXCL1 cDNA ORF Clone, Rat, N-His tag RG80039-NH
    CXCL1 cDNA ORF Clone, Rat, C-HA tag RG80039-CY
    CXCL1 cDNA ORF Clone, Rat, N-HA tag RG80039-NY
    CXCL1 cDNA ORF Clone, Rat, C-Myc tag RG80039-CM
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    CXCL1 qPCR Primer Pairs, Mouse, Related Products

    Product Name Catalog#(PDF)
    CXCL1 cDNA ORF Clone in Cloning Vector, Mouse MG50150-M
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    CXCL1 Lentiviral cDNA ORF Clone, Mouse, C-GFPSpark® tag MG50150-ACGLN
    CXCL1 cDNA ORF Clone, Mouse, C-OFPSpark® tag MG50150-ACR
    CXCL1 cDNA ORF Clone, Mouse, C-DDK (Flag®) tag MG50150-CF
    CXCL1 cDNA ORF Clone, Mouse, N-DDK (Flag®) tag MG50150-NF
    CXCL1 cDNA ORF Clone, Mouse, C-His tag MG50150-CH
    CXCL1 cDNA ORF Clone, Mouse, N-His tag MG50150-NH
    CXCL1 cDNA ORF Clone, Mouse, C-HA tag MG50150-CY
    CXCL1 cDNA ORF Clone, Mouse, N-HA tag MG50150-NY
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    CXCL1 qPCR Primer Pairs, Human, Related Products

    Product Name Catalog#(PDF)
    CXCL1 cDNA ORF Clone in Cloning Vector, Human HG10877-M
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    CXCL1 cDNA ORF Clone, Human, C-GFPSpark® tag HG10877-ACG
    CXCL1 Lentiviral cDNA ORF Clone, Human, C-GFPSpark® tag HG10877-ACGLN
    CXCL1 cDNA ORF Clone, Human, C-OFPSpark® tag HG10877-ACR
    CXCL1 cDNA ORF Clone, Human, C-DDK (Flag®) tag HG10877-CF
    CXCL1 cDNA ORF Clone, Human, N-DDK (Flag®) tag HG10877-NF
    CXCL1 cDNA ORF Clone, Human, C-His tag HG10877-CH
    CXCL1 cDNA ORF Clone, Human, N-His tag HG10877-NH
    CXCL1 cDNA ORF Clone, Human, C-HA tag HG10877-CY
    CXCL1 cDNA ORF Clone, Human, N-HA tag HG10877-NY
    CXCL1 cDNA ORF Clone, Human, C-Myc tag HG10877-CM
    CXCL1 cDNA ORF Clone, Human, N-Myc tag HG10877-NM
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