CSF1R qPCR Primer Pairs, Mouse

Cat: MP200059
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CSF1R qPCR Primer Pairs, Mouse General Information
Target Details
Species:
Mouse
Product Details
Oligo-Type:
qPCR Primers
Component:
1 vial of lyophilized qPCR primer mix (1 nmol each primer, sufficient for 200 numbers of 25 μl reactions).
QPCR Primer Description:
Verified forward and reverse primers for analyzing the quantitative expression of gene.
Application & Quality
Application:
SYBR® Green-based quantitative real-time PCR (qPCR).
Quality Control:
The primer mix has been verified to generate satisfactory qPCR data on Roche Applied-science LightCycler® 480 Ⅱ.
Storage & Shipping
Shipping:
Lyophilized qPCR primer mix is shipped at ambiente temperatura
Storage:
The lyophilized product is stable for one year from date of receipt when stored at -20℃. The suspended product is stable for six months from date of receipt when stored at -20℃.

***Sino biological qEASY qPCR primer pairs are used for SYBR Green-based real-time RT-PCR, The primers are designed by using SBI's proprietary primer design algorithm. Our primer collection covers the entire human genomes. It can be widely applied in the quantitative analysis of gene expression.***

Features and Advantages
Unique Primer Design
To avoid genomic DNA amplification, at least one primer is designed crosses the junction of exons according to the conserved region of a specific gene with all variants.
Strict Validation Process
Confirmed in positive organizations; screened the primer with high specificity and high sensitivity.
Uniform PCR conditions, Saving time and cost
~100% amplification curve, ensuring the accuracy of the RNA quantitative
CSF1R qPCR Primer Pairs, Mouse Alternative Names
AI323359 qPCR Primer Pairs, Mouse;CD115 qPCR Primer Pairs, Mouse;CSF-1R qPCR Primer Pairs, Mouse;Csfmr qPCR Primer Pairs, Mouse;Fim-2 qPCR Primer Pairs, Mouse;Fms qPCR Primer Pairs, Mouse;M-CSF-R qPCR Primer Pairs, Mouse;M-CSFR qPCR Primer Pairs, Mouse
CSF1R Background Information

M-CSFR encoded by the proto-oncogene c-fms is the receptor for colony stimulating factor 1 (CSF1R), a cytokine involved in the proliferation, differentiation, and activation of macrophages. This cell surface glycoprotein is consisted by an extracellular ligand-binding domain, a single membrane-spanning segment, and an intracellular tyrosine kinase domain. Binding of CSF1 activates the receptor kinase, leading to "autophosphorylation" of receptor subunits and the concomitant phosphorylation of a series of cellular proteins on tyrosine residues. CSF1R is a tyrosine kinase receptor that is absolutely required for macrophage differentiation and thus occupies a central role in hematopoiesis. CSF1 and its receptor (CSF1R, product of c-fms proto-oncogene) were initially implicated as essential for normal monocyte development as well as for trophoblastic implantation. This apparent role for CSF1/CSF1R in normal mammary gland development is very intriguing because this receptor/ligand pair has also been found to be important in the biology of breast cancer in which abnormal expression of CSF1 and its receptor correlates with tumor cell invasiveness and adverse clinical prognosis. Tumor cell expression of CSF1R is under the control of several steroid hormones (glucocorticoids and progestins) and the binding of several bHLH transcription factors, while tumor cell expression of CSF-1 appears to be regulated by other hormones, some of which are involved in normal lactogenic differentiation. However, studies have demonstrated that CSF1 and CSF1R have additional roles in mammary gland development during pregnancy and lactation. The role of CSF1 and CSF1R in normal and neoplastic mammary development that may elucidate potential relationships of growth factor-induced biological changes in the breast during pregnancy and tumor progression.

Full Name
colony stimulating factor 1 receptor
References
  • Sherr CJ. (1990) The colony-stimulating factor 1 receptor: pleiotropy of signal-response coupling. Lymphokine Res. 9(4): 543-8.
  • Kacinski BM. (1997) CSF-1 and its receptor in breast carcinomas and neoplasms of the female reproductive tract. Mol Reprod Dev. 46(1): 71-4.
  • Sapi E, et al. (1999) The role of CSF-1 in normal and neoplastic breast physiology. Proc Soc Exp Biol Med. 220(1): 1-8.
  • Sapi E. (2004) The role of CSF-1 in normal physiology of mammary gland and breast cancer: an update. Exp Biol Med (Maywood). 229(1): 1-11.
  • Bonifer C, et al. (2008) The transcriptional regulation of the Colony-Stimulating Factor 1 Receptor (csf1r) gene during hematopoiesis. Front Biosci. 13: 549-60.
  • CSF1R qPCR Primer Pairs, Canine, Related Products

    Product Name Catalog#(PDF)
    CSF1R cDNA ORF Clone in Cloning Vector, Canine DG70086-G
    CSF1R cDNA ORF Clone, Canine, untagged DG70086-UT
    CSF1R cDNA ORF Clone, Canine, C-GFPSpark® tag DG70086-ACG
    CSF1R Lentiviral cDNA ORF Clone, Canine, C-GFPSpark® tag DG70086-ACGLN
    CSF1R cDNA ORF Clone, Canine, C-OFPSpark® tag DG70086-ACR
    CSF1R cDNA ORF Clone, Canine, C-DDK (Flag®) tag DG70086-CF
    CSF1R cDNA ORF Clone, Canine, N-DDK (Flag®) tag DG70086-NF
    CSF1R cDNA ORF Clone, Canine, C-His tag DG70086-CH
    CSF1R cDNA ORF Clone, Canine, N-His tag DG70086-NH
    CSF1R cDNA ORF Clone, Canine, C-HA tag DG70086-CY
    CSF1R cDNA ORF Clone, Canine, N-HA tag DG70086-NY
    CSF1R cDNA ORF Clone, Canine, C-Myc tag DG70086-CM
    CSF1R cDNA ORF Clone, Canine, N-Myc tag DG70086-NM

    CSF1R qPCR Primer Pairs, Rhesus, Related Products

    Product Name Catalog#(PDF)
    CSF1R cDNA ORF Clone in Cloning Vector, Rhesus CG90035-G
    CSF1R cDNA ORF Clone, Rhesus, untagged CG90035-UT
    CSF1R cDNA ORF Clone, Rhesus, C-GFPSpark® tag CG90035-ACG
    CSF1R Lentiviral cDNA ORF Clone, Rhesus, C-GFPSpark® tag CG90035-ACGLN
    CSF1R cDNA ORF Clone, Rhesus, C-OFPSpark® tag CG90035-ACR
    CSF1R cDNA ORF Clone, Rhesus, C-DDK (Flag®) tag CG90035-CF
    CSF1R cDNA ORF Clone, Rhesus, N-DDK (Flag®) tag CG90035-NF
    CSF1R cDNA ORF Clone, Rhesus, C-His tag CG90035-CH
    CSF1R cDNA ORF Clone, Rhesus, N-His tag CG90035-NH
    CSF1R cDNA ORF Clone, Rhesus, C-HA tag CG90035-CY
    CSF1R cDNA ORF Clone, Rhesus, N-HA tag CG90035-NY
    CSF1R cDNA ORF Clone, Rhesus, C-Myc tag CG90035-CM
    CSF1R cDNA ORF Clone, Rhesus, N-Myc tag CG90035-NM

    CSF1R qPCR Primer Pairs, Mouse, Related Products

    Product Name Catalog#(PDF)
    CSF1R cDNA ORF Clone in Cloning Vector, Mouse MG50059-M
    CSF1R cDNA ORF Clone, Mouse, untagged MG50059-UT
    CSF1R cDNA ORF Clone, Mouse, C-GFPSpark® tag MG50059-ACG
    CSF1R Lentiviral cDNA ORF Clone, Mouse, C-GFPSpark® tag MG50059-ACGLN
    CSF1R cDNA ORF Clone, Mouse, C-OFPSpark® tag MG50059-ACR
    CSF1R cDNA ORF Clone, Mouse, C-DDK (Flag®) tag MG50059-CF
    CSF1R cDNA ORF Clone, Mouse, N-DDK (Flag®) tag MG50059-NF
    CSF1R cDNA ORF Clone, Mouse, C-His tag MG50059-CH
    CSF1R cDNA ORF Clone, Mouse, N-His tag MG50059-NH
    CSF1R cDNA ORF Clone, Mouse, C-HA tag MG50059-CY
    CSF1R cDNA ORF Clone, Mouse, N-HA tag MG50059-NY
    CSF1R cDNA ORF Clone, Mouse, C-Myc tag MG50059-CM
    CSF1R cDNA ORF Clone, Mouse, N-Myc tag MG50059-NM

    CSF1R qPCR Primer Pairs, Human, Related Products

    Product Name Catalog#(PDF)
    CSF1R cDNA ORF Clone in Cloning Vector, Human HG10161-M
    CSF1R cDNA ORF Clone, Human, untagged HG10161-UT
    CSF1R Lentiviral cDNA ORF Clone, Human, C-GFPSpark® tag HG10161-ACGLN
    CSF1R cDNA ORF Clone, Human, C-GFPSpark® tag HG10161-ACG
    CSF1R cDNA ORF Clone, Human, C-OFPSpark® tag HG10161-ACR
    CSF1R cDNA ORF Clone, Human, C-DDK (Flag®) tag HG10161-CF
    CSF1R cDNA ORF Clone, Human, N-DDK (Flag®) tag HG10161-NF
    CSF1R cDNA ORF Clone, Human, C-His tag HG10161-CH
    CSF1R cDNA ORF Clone, Human, N-His tag HG10161-NH
    CSF1R cDNA ORF Clone, Human, C-HA tag HG10161-CY
    CSF1R cDNA ORF Clone, Human, N-HA tag HG10161-NY
    CSF1R cDNA ORF Clone, Human, C-Myc tag HG10161-CM
    CSF1R cDNA ORF Clone, Human, N-Myc tag HG10161-NM
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