CADM4 cDNA ORF Clone, Mouse, N-DDK (Flag®) tag

Cat: MG50501-NF
Contact us:
+86-400-890-9989
order@sinobiological.com
Distributors
All CADM4 Reagents
CRO Services
Product recommended

All CADM4 Reagents
CADM4 cDNA ORF Clone, Mouse, N-DDK (Flag®) tag General Information
Gene
Species
Mouse
NCBI Ref Seq
RefSeq ORF Size
1167 bp
Description
Full length Clone DNA of Mouse cell adhesion molecule 4 with N terminal Flag tag.
Plasmid
Promoter
Enhanced CMV promoter
Vector
pCMV3-SP-N-FLAG
Tag Sequence
FLAG Tag Sequence: GATTACAAGGATGACGACGATAAG
Sequencing Primers
T7( 5' TAATACGACTCACTATAGGG 3' )
BGH( 5' TAGAAGGCACAGTCGAGG 3' )
Quality Control
The plasmid is confirmed by full-length sequencing.
Screening
Antibiotic in E.coli
Kanamycin
Antibiotic in Mammalian cell
Hygromycin
Application
Stable or Transient mammalian expression
Storage & Shipping
Shipping
Each tube contains lyophilized plasmid.
Storage
The lyophilized plasmid can be stored at ambient temperature for three months.

**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**

CADM4 cDNA ORF Clone, Mouse, N-DDK (Flag®) tag Alternative Names
Igdf4c cDNA ORF Clone, Mouse;Igsf4c cDNA ORF Clone, Mouse;Tsll2 cDNA ORF Clone, Mouse
CADM4 Background Information

Immunoglobulin superfamily member 4C (IGSF4C), also known as CADM4 or NECL-4, is an immunoglobulin (Ig) superfamily molecule showing significant homology with a lung tumor suppressor, TSLC1. CADM4/IGSF4C/NECL-4 protein is mainly expressed in the kidney, bladder, and prostate in addition to the brain. Experiments have reported the biological significance of CADM4/IGSF4C/NECL-4 in the urinary tissues. An immunohistochemical study reveals that CADM4 is expressed at the cell-cell attachment sites in the renal tubules, the transitional epithelia of the bladder, and the glandular epithelia of the prostate. IGSF4-immunoreactivity (IR) was observed diffusely in the telencephalic wall, whereas it became rather confined to the subplate, the cortical plate and the subventricular zone as the development proceeded. IGSF4-IR gradually decreased after birth and disappeared in adulthood. IGSF4 remained at low levels throughout embryonic stage, whereas it increased after birth. These spatiotemporal patterns of the expression suggest that IGSF4 plays crucial roles in the development of both telencephalon and cerebellum. CADM4/IGSF4C/NECL-4 is ectopically expressed in adult T-cell leukemia (ATL) cells, providing not only a diagnostic marker for ATL, but also a possible therapeutic target against its invasion. The distinct roles of CADM4/IGSF4C/NECL-4 in the oncogenesis of carcinomas and ATL could be due to tissue-specific differences in the downstream cascades, and is a novel concept with respect to cell adhesion in human oncogenesis.

Full Name
cell adhesion molecule 4
References
  • Williams YN, et al. (2006) Cell adhesion and prostate tumor-suppressor activity of TSLL2/IGSF4C, an immunoglobulin superfamily molecule homologous to TSLC1/IGSF4. Oncogene. 25(10): 1446-53.
  • Ohta Y, et al. (2005) Spatiotemporal patterns of expression of IGSF4 in developing mouse nervous system. Brain Res Dev Brain Res. 156(1): 23-31.
  • Shingai T, et al. (2003) Implications of nectin-like molecule-2 /IGSF4 /RA175 /SgIGSF /TSLC1 /SynCAM1 in cell-cell adhesion and transmembrane protein localization in epithelial cells. J Biol Chem. 278(37): 35421-7.
  • CADM4 cDNA ORF Clone, Mouse, Related Products

    Product Name Catalog#(PDF)
    CADM4 cDNA ORF Clone in Cloning Vector, Mouse MG50501-M
    CADM4 cDNA ORF Clone, Mouse, untagged MG50501-UT
    CADM4 cDNA ORF Clone, Mouse, C-GFPSpark® tag MG50501-ACG
    CADM4 Lentiviral cDNA ORF Clone, Mouse, C-GFPSpark® tag MG50501-ACGLN
    CADM4 cDNA ORF Clone, Mouse, C-OFPSpark® tag MG50501-ACR
    CADM4 cDNA ORF Clone, Mouse, C-DDK (Flag®) tag MG50501-CF
    CADM4 cDNA ORF Clone, Mouse, C-His tag MG50501-CH
    CADM4 cDNA ORF Clone, Mouse, N-His tag MG50501-NH
    CADM4 cDNA ORF Clone, Mouse, C-HA tag MG50501-CY
    CADM4 cDNA ORF Clone, Mouse, N-HA tag MG50501-NY
    CADM4 cDNA ORF Clone, Mouse, C-Myc tag MG50501-CM
    CADM4 cDNA ORF Clone, Mouse, N-Myc tag MG50501-NM
    CADM4 qPCR Primer Pairs, Mouse MP200495

    CADM4 cDNA ORF Clone, Human, Related Products

    Product Name Catalog#(PDF)
    CADM4 cDNA ORF Clone in Cloning Vector, Human HG16033-G
    CADM4 cDNA ORF Clone, Human, untagged HG16033-UT
    CADM4 cDNA ORF Clone, Human, C-GFPSpark® tag HG16033-ACG
    CADM4 Lentiviral cDNA ORF Clone, Human, C-GFPSpark® tag HG16033-ACGLN
    CADM4 cDNA ORF Clone, Human, C-OFPSpark® tag HG16033-ACR
    CADM4 cDNA ORF Clone, Human, C-DDK (Flag®) tag HG16033-CF
    CADM4 cDNA ORF Clone, Human, N-DDK (Flag®) tag HG16033-NF
    CADM4 cDNA ORF Clone, Human, C-His tag HG16033-CH
    CADM4 cDNA ORF Clone, Human, N-His tag HG16033-NH
    CADM4 cDNA ORF Clone, Human, C-HA tag HG16033-CY
    CADM4 cDNA ORF Clone, Human, N-HA tag HG16033-NY
    CADM4 cDNA ORF Clone, Human, C-Myc tag HG16033-CM
    CADM4 cDNA ORF Clone, Human, N-Myc tag HG16033-NM
    info info
    添加购物车成功! 添加购物车失败!