Monocyte / Macrophage

Sino biological offers a comprehensive set of tools for natural killer cell related research. These include recombinant proteins, monoclonal/polyclonal antibodies and ORF cDNA clones.

Monocyte / Macrophage Related Areas

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Monocyte / Macrophage Background

Monocyte is a type of white blood cells that originate in the bone marrow and develop through the following steps: stem cell - committed stem cell - monoblast - promonocyte – monocyte. Monocytes travel through bloodstream to tissues throughout the body where they mature and differentiate into tissue-specific macrophage populations. Monocytes constitute 3% - 8% of the leukocytes circulating in the blood. An increased number of monocytes in the blood, referred to as monocytosis, occurs in the processes including, chronic inflammation, stress response, hyperadrenocorticism, and in some infectious diseases. Monocytes and macrophages are phagocytes, acting in both non-specific defenses (innate immunity) as well as to help initiate specific defense mechanisms (adaptive immunity). Macrophages are professional antigen-presenting cells (APCs). After digesting a pathogen, a macrophage displays a fragment of the antigen to a corresponding helper T cell. In addition, monocytes and macrophages release substances that stimulate other cells of the immune system.

Monocyte / Macrophage Related Studies

1. Härkönen PL, et al. (2006) Monocyte-macrophage system as a target for estrogen and selective estrogen receptor modulators. Ann N Y Acad Sci. 1089:218-27.
2. Randolph GJ, et al. (2008) Antigen presentation by monocytes and monocyte-derived cells. Curr Opin Immunol. 20(1):52-60.
3. Fischer-Smith T, et al. (2008) Monocyte/macrophage trafficking in acquired immunodeficiency syndrome encephalitis: lessons from human and nonhuman primate studies. J Neurovirol. 14(4):318-26.
4. Kilareski EM, et al. (2009) Regulation of HIV-1 transcription in cells of the monocyte-macrophage lineage. Retrovirology. 6:118.