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Midkine Protein, Antibody, ELISA Kit, cDNA Clone

Midkine Related Areas

Midkine Related Pathways

Midkine Related Product

    Midkine Summary & Protein Information

    Midkine Related Information

    Midkine Background

    Gene Summary: OMIM - description for Midkine :
    General information above from NCBI
    Subunit structure: Homodimer. Interacts with ALK.
    Subcellular location: Secreted.
    Tissue specificity: Expressed in various tumor cell lines. In insulinoma tissue predominantly expressed in precancerous lesions.
    Induction: By heparin and retinoic acid.
    Sequence similarity: Belongs to the pleiotrophin family.C
    General information above from UniProt

    Midkine (MK or MDK) also known as neurite growth-promoting factor 2 (NEGF2) is a basic heparin-binding growth factor of low molecular weight, and forms a family with pleiotrophin. Midkine is a retinoic acid-responsive, heparin-binding growth factor expressed in various cell types during embryogenesis. It promotes angiogenesis, cell growth, and cell migration. Midkine is also expressed in several carcinomas, suggesting that it may play a role in tumorigenesis, perhaps through its effects on angiogenesis. Midkine binds anaplastic lymphoma kinase (ALK) which induces ALK activation and subsequent phosphorylation of the insulin receptor substrate (IRS1), followed by the activation of mitogen-activated protein kinase (MAPK) and PI3-kinase, and the induction of cell proliferation. Midkine is involved in neointima formation after arterial injury, possibly by mediating leukocyte recruitment. Also involved in early fetal adrenal gland development. Midkine exhibited increased expression in the breast carcinomas but showed much lower expression in the normal breast tissue. Thus, it can be used as breast carcinomas marker.

    Midkine Alternative Name

    Midkine Related Studies

  • Kadomatsu K, et al. (2004) Midkine and pleiotrophin in neural development and cancer. Cancer Lett. 204(2): 127-43.
  • Muramatsu H, et al. (1993) Midkine, a retinoic acid-inducible growth/differentiation factor: immunochemical evidence for the function and distribution. Dev Biol. 159(2): 392-402.
  • Muramatsu T. (2002) Midkine and pleiotrophin: two related proteins involved in development, survival, inflammation and tumorigenesis. J Biochem. 132(3): 359-71.
  • Kadomatsu K, et al. (2004) Midkine and pleiotrophin in neural development and cancer. Cancer Lett. 204(2): 127-43.
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