Mouse Meteorin / METRN Protein

Meteorin, glial cell differentiation regulator Protein Datasheet

Meteorin / METRN Protein Product Information

• Synonym: METRN, Hyrac
• Protein Construction: A DNA sequence encoding the mouse METRN (Q8C1Q4-1)(Gly22-Asp291) was expressed with the fused Fc region of human IgG1 at the N-terminus.
• Source: Mouse
• Expression Host: Human Cells

Meteorin / METRN Protein QC Testing

• Purity: > 85 % as determined by SDS-PAGE
• Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method
• Stability: Samples are stable for up to twelve months from date of receipt at -70℃
• Predicted N terminal: Glu
• Molecular Mass: The recombinant mouse METRN/Fc comprises 526 amino acids and has a predicted molecular mass of 58.4 kDa. The apparent molecular mass of the protein is approximately 57 kDa in SDS-PAGE under reducing conditions due to glycosylation.
• Formulation: Lyophilized from sterile PBS,pH7.4.
  1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
  2. Please contact us for any concerns or special requirements.
• SDS-PAGE: Meteorin / METRN protein

Meteorin / METRN Protein Usage Guide

• Storage: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Meteorin / METRN Protein Description

Meteorin is a novel secreted protein that is expressed in undifferentiated neural progenitors and in the astrocyte lineage, including radial glia. Meteorin is highly expressed in astrocytes of the brain and the retina during late embryonic and postnatal stages of development. Meteorin selectively promoted astrocyte formation from mouse cerebrocortical neurospheres in differentiation culture, whereas it induced cerebellar astrocytes to become radial glia. Meteorin also induced axonal extension in small and intermediate neurons of sensory ganglia by activating nearby satellite glia.

References

1. Martin J. et al., 2004, Nature. 432 (7020): 988-94.
2. Nishino J. et al., 2004, EMBO J. 23 (9): 1998-2008.
3. Ota T. et al., 2004, Nat Genet. 36 (1): 40-5.