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Mesenchymal Stem Cell Negative Marker

Sino Biological provides a comprehensive set of tools for mesenchymal stem cell negative marker related studies, including recombinant proteins, antibodies (rabbit MAb & PAb, mouse MAb), ELISA kits, and ORF cDNA clones.

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    Mesenchymal Stem Cell Negative Marker Background

    Mesenchymal stem cells (MSCs) are multipotent stem cells that are able to self-renew and differentiate into a variety of cell types, including adipocytes (fat cells), chondrocytes (cartilage cells), myocytes (muscle cells) and osteoblasts (bone cells). Although mesenchymal stem cells are traditionally isolated from bone marrow, more recent reports have detailed the isolation of cells with MSC characteristics from other tissues, such as cord blood, peripheral blood, skeletal muscle,fetal liver and lung, and synovium. Mesenchymal stem cells have long and thin cell bodies containing a large, round nucleus with a prominent nucleolus which is surrounded by finely dispersed chromatin particles, giving the nucleus a clear appearance. Mesenchymal stem cells are a distinct entity to the mesenchyme, which is derived from the mesoderm and is able to differentiate into hematopoietic cells.

    Mesenchymal Stem Cell Negative Marker References

      1. Kamiya K, et al. (2007) Mesenchymal stem cell transplantation accelerates hearing recovery through the repair of injured cochlear fibrocytes. Am J Pathol. 171(1):214-26.
      2. Mader EK, et al. (2009) Mesenchymal stem cell carriers protect oncolytic measles viruses from antibody neutralization in an orthotopic ovarian cancer therapy model. Clin Cancer Res. 15(23):7246-55.
      3. Ding Y, et al. (2010) Mesenchymal stem-cell immunosuppressive capabilities: therapeutic implications in islet transplantation. Transplantation. 89(3):270-3.
      4. Lu C, et al. (2010) MT1-MMP controls human mesenchymal stem cell trafficking and differentiation. Blood. 115(2):221-9.