MYC Associated Factor X

MYC associated factor X contains 1 basic helix-loop-helix (bHLH) domain and belongs to MAX family. It is highly expressed in the brain, heart and lung while lower levels are seen in the liver, kidney and skeletal muscle. MYC associated factor X can form homodimers and heterodimers with other family members, which include Mad, Mxi1 and Myc. Myc is an oncoprotein implicated in cell proliferation, differentiation and apoptosis. The homodimers and heterodimers compete for a common DNA target site (the E box) and rearrangement among these dimer forms provides a complex system of transcriptional regulation. MYC associated factor X may also repress transcription via the recruitment of a chromatin remodeling complex containing H3 'Lys-9' histone methyltransferase activity. Multiple alternatively spliced transcript variants have been described for MYC associated factor X gene but the full-length nature for some of them is unknown.

MYC Associated Factor X Related Areas

Signal Transduction>>Transcription Factor & Regulator>> MYC associated factor X

MYC Associated Factor X Alternative Names

MGC10775, MGC11225, MGC18164, MGC34679, MGC36767, bHLHd4, bHLHd5, bHLHd6, bHLHd7, bHLHd8, orf1, class D basic helix-loop-helix protein 4, helix-loop-helix zipper protein, protein max [Homo sapiens]

AA960152, AI875693, bHLHd4, bHLHd5, bHLHd6, bHLHd7, bHLHd8, myc-associated factor X, myc-binding novel HLH/LZ protein, protein max, protein myn [Mus musculus]

Summaries for MYC Associated Factor X

Entrez Gene summary for MYC Associated Factor X:

The protein encoded by MAX gene is a member of the basic helix-loop-helix leucine zipper (bHLHZ) family of transcription factors. It is able to form homodimers and heterodimers with other family members, which include Mad, Mxi1 and Myc. Myc is an oncoprotein implicated in cell proliferation, differentiation and apoptosis. The homodimers and heterodimers compete for a common DNA target site (the E box) and rearrangement among these dimer forms provides a complex system of transcriptional regulation. Multiple alternatively spliced transcript variants have been described for MAX gene but the full-length nature for some of them is unknown. [provided by RefSeq, Jul 2008]

OMIM - description for MYC Associated Factor X:

The MYC protooncogene encodes a DNA-binding factor that can activate and repress transcription. Via this mechanism, MYC regulates expression of numerous target genes that control key cellular functions, including cell growth and cell cycle progression. MYC also has a critical role in DNA replication. Deregulated MYC expression resulting from various types of genetic alterations leads to constitutive MYC activity in a variety of cancers and promotes oncogenesis (Dominguez-Sola et al., 2007).

Wikipedia summary for MYC Associated Factor X:

Protein max also known as myc-associated factor X is a protein that in humans is encoded by the MAX gene.

Human MYC Associated Factor X Protein General Information

 

• Protein names: MYC associated factor X
• Sequence length: 151 AA.
• Sequence similarities: Contains 1 basic helix-loop-helix (bHLH) domain.

General information above from UniProt

Function for MYC Associated Factor X Protein

Genatlas:

• MYC-MAX complex is a transcriptional activator, whereas the MAD-MAX complex is a repressor
• MYC associated factor X is the obligatory DNA-binding and dimerization partner for all the bHLHZip regulators of the Myc/Max/Mad network, including the Myc family of oncoproteins and the Mad family of Myc antagonists, which recognize E-box DNA elements in the regulatory regions of target genes
• MYC associated factor X is a constitutively expressed and phosphorylated protein
• MYC associated factor X is key role for the MYC-MAX-MXD1 network in the development and progression of neural crest tumors

Phenotype Information for MYC Associated Factor X

• Gene/Locus: MYC
• Phenotype: Burkitt lymphoma

Phenotype Information for MYC Associated Factor X from OMIM (Online Mendelian Inheritance in Man)