MTSS1 Protein

Metastasis suppressor 1

MTSS1 Products

MTSS1 Protein, Recombinant

Molecule	Species	Description	Cat. No
MTSS1	Human	MTSS1 (aa1-250) Protein, Recombinant, with MBP tag	13085-H10E

MTSS1 cDNA Clone

Molecule	Species	Description	Cat. No
MTSS1	Human	Human MTSS1 cDNA Clone / ORF Clone	HG13085-G

MTSS1 Related Areas

Signal Transduction>>Transcription Factor & Regulator>>MTSS1

MTSS1 Alternative Names

MTSS1, DKFZp781P2223, FLJ44694, KIAA0429, MIM, MIMA, MIMB [Homo sapiens]

Mtss1, 2310003N14Rik, BC024131, D130001D01Rik, MGC37896, Mim, mKIAA0429 [Mus musculus]

MTSS1 Background

MTSS1 (Metastasis suppressor 1), also known as Missing in metastasis (MIM), is a tissue-specific regulator of plasma membrane dynamics. MTSS1 is well described for its function as a metastasis suppressor gene and is expressed in a variety of tissues. MTSS1 might be involved in shaping neuronal membranes in vivo. MTSS1 deforms phosphoinositide-rich membranes through its I-BAR domain and interacts with actin monomers through its WH2 domain. MTSS1/MIM was first identified as a metastasis suppressor missing in metastatic bladder carcinoma cell lines. MTSS1 is a prognostic indicator of disease-free survival in breast cancer patients and demonstrates the ability to play a role in governing the metastatic nature of breast cancer cells. MTSS1 may serve as a useful biomarker for the prediction of outcome of gastric cancer. The down-regulation of MTSS1 that may be caused by DNA methylation was also observed in many other types of cancer.Recent work proposed that MIM also potentiates Sonic hedgehog (Shh)-induced gene expression. MTSS1 as a multiple functional molecular player and has an important role in development, carcinogenesis and metastasis.

MTSS1 Related Studies

1. Hayn-Leichsenring G, et al. (2011) Cellular distribution of metastasis suppressor 1 and the shape of cell bodies are temporarily altered in Engrailed-2 overexpressing cerebellar Purkinje cells. Neuroscience. 189: 68-78.
2. Xie F, et al. (2011) MTSS1: a multifunctional protein and its role in cancer invasion and metastasis. Front Biosci (Schol Ed). 3: 621-31.
3. Saarikangas J, et al. (2011) Missing-in-metastasis MIM/MTSS1 promotes actin assembly at intercellular junctions and is required for integrity of kidney epithelia. J Cell Sci. 2124(Pt 8): 1245-55.
4. Parr C, et al. (2009) Metastasis suppressor 1 (MTSS1) demonstrates prognostic value and anti-metastatic properties in breast cancer. Eur J Cancer. 45(9): 1673-83.