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MTSS1  Protein, Antibody, ELISA Kit, cDNA Clone

Expression host: E. coli  
50 µg 
20 µg 
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MTSS1 Related Area

MTSS1 Related Pathways

    MTSS1 Summary & Protein Information

    MTSS1 Background

    Gene Summary: OMIM - description for MTSS1:
    General information above from NCBI
    Subunit structure: Binds to actin. Binds to the cytoplasmic domain of receptor protein tyrosine phosphatase delta. {ECO:0000269|PubMed:12570871}.
    Domain: The WH2 motif at the C-terminus binds to actin monomers.
    Subcellular location: Cytoplasm, cytoskeleton.
    Tissue specificity: Expressed in many tissues, including spleen, thymus, prostate, testis, uterus, colon, and peripheral blood. {ECO:0000269|PubMed:12082544}.
    Sequence similarity: Belongs to the MTSS1 family. {ECO:0000305}.; Contains 1 IMD (IRSp53/MIM homology) domain. {ECO:0000255|PROSITE-ProRule:PRU00668}.; Contains 1 WH2 domain. {ECO:0000255|PROSITE-ProRule:PRU00406}.
    General information above from UniProt

    MTSS1 (Metastasis suppressor 1), also known as Missing in metastasis (MIM), is a tissue-specific regulator of plasma membrane dynamics. MTSS1 is well described for its function as a metastasis suppressor gene and is expressed in a variety of tissues. MTSS1 might be involved in shaping neuronal membranes in vivo. MTSS1 deforms phosphoinositide-rich membranes through its I-BAR domain and interacts with actin monomers through its WH2 domain. MTSS1/MIM was first identified as a metastasis suppressor missing in metastatic bladder carcinoma cell lines. MTSS1 is a prognostic indicator of disease-free survival in breast cancer patients and demonstrates the ability to play a role in governing the metastatic nature of breast cancer cells. MTSS1 may serve as a useful biomarker for the prediction of outcome of gastric cancer. The down-regulation of MTSS1 that may be caused by DNA methylation was also observed in many other types of cancer.Recent work proposed that MIM also potentiates Sonic hedgehog (Shh)-induced gene expression. MTSS1 as a multiple functional molecular player and has an important role in development, carcinogenesis and metastasis.

    MTSS1 Alternative Name

    MIM,MIMA,MIMB, [homo-sapiens]
    DKFZp781P2223,KIAA0429,MIM,MIMA,FLJ44694,MIMB,MTSS1, [human]
    2310003N14Rik,BC024131,D130001D01Rik,Mim,MGC37896,mKIAA0429,Mtss1, [mouse]
    Mim,BC024131,mKIAA0429,2310003N14Rik,D130001D01Rik, [mus-musculus]

    MTSS1 Related Studies

  • Hayn-Leichsenring G, et al. (2011) Cellular distribution of metastasis suppressor 1 and the shape of cell bodies are temporarily altered in Engrailed-2 overexpressing cerebellar Purkinje cells. Neuroscience. 189: 68-78.
  • Xie F, et al. (2011) MTSS1: a multifunctional protein and its role in cancer invasion and metastasis. Front Biosci (Schol Ed). 3: 621-31.
  • Saarikangas J, et al. (2011) Missing-in-metastasis MIM/MTSS1 promotes actin assembly at intercellular junctions and is required for integrity of kidney epithelia. J Cell Sci. 2124(Pt 8): 1245-55.
  • Parr C, et al. (2009) Metastasis suppressor 1 (MTSS1) demonstrates prognostic value and anti-metastatic properties in breast cancer. Eur J Cancer. 45(9): 1673-83.