MST4

Mediator of cell growth. Modulates apoptosis

MST4 Related Areas

 

MST4 Alternative Names

MST4, RP6-213H19.1, MASK, Mst3 and SOK1-related kinase, STE20-like kinase MST4, mammalian Ste20-like protein kinase 4, mammalian sterile 20-like 4, serine/threonine protein kinase MASK

Summaries for MST4

Entrez Gene summary for MST4:

The product of this gene is a member of the GCK group III family of kinases, which are a subset of the Ste20-like kinases. The encoded protein contains an amino-terminal kinase domain, and a carboxy-terminal regulatory domain that mediates homodimerization. The protein kinase localizes to the Golgi apparatus and is specifically activated by binding to the Golgi matrix protein GM130. It is also cleaved by caspase-3 in vitro, and may function in the apoptotic pathway. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.

OMIM - description for MST4:

MST4 belongs to a family of proteins that share similarity with a budding yeast serine/threonine kinase, sterile-20 (Ste20), and have roles in mitogen-activated protein kinase (MAPK; see 176948) signaling during cytoskeletal rearrangement, morphogenesis, apoptosis, and other diverse cellular events

Wikipedia summary for MST4:

Serine/threonine protein kinase MST4, also known as RP6-213H19.1, is a human gene. The product of this gene is a member of the GCK group III family of kinases, which are a subset of the Ste20-like kinases. The encoded protein contains an amino-terminal kinase domain, and a carboxy-terminal regulatory domain that mediates homodimerization. The protein kinase localizes to the Golgi apparatus and is specifically activated by binding to the Golgi matrix protein GM130. It is also cleaved by caspase-3 in vitro, and may function in the apoptotic pathway. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined

Human MST4 Protein General Information

 

• Protein names: Recommended name: Serine/threonine-protein kinase MST4
• Sequence length: 416 AA.
• Sequence similarities: Homodimer. Interacts with PDCD10 and GOLGA2
• Subcellular location: Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Note: Localizes to the Golgi apparatus.
• Tissue specificity: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. Contains 1 protein kinase domain.

General information above from UniProt

Function for MST4 Protein

UniProtKB:

Mediator of cell growth. Modulates apoptosis

Genatlas:

• MST4 may be involved in protein amino acid phosphorylation
• MST4 is involved in the apoptotic machinery
• MST4 is implicated in Golgi positioning and integrity
• MST4 can be found in at least two separate complexes, one with STRIPAK and one with GOLGA2
• activated and relocated to the cell periphery after oxidative stress, and involved in ERM phosphorylation

Homology for human MST4

• homolog to murine Ste20 yeast homolog