Rat MSR1 / SCARA1 Protein

Macrophage scavenger receptor 1 Protein Datasheet

MSR1 / SCARA1 Protein Product Information

• Synonym: MSR1
• Protein Construction: A DNA sequence encoding the rat MSR1 (Trp79-Ser454) was expressed, fused with the Fc region of human IgG1 at the N-terminus.
• Source: Rat
• Expression Host: Human Cells

MSR1 / SCARA1 Protein QC Testing

• Purity: > 95 % as determined by SDS-PAGE
• Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method
• Stability: Samples are stable for up to twelve months from date of receipt at -70℃
• Predicted N terminal: Glu
• Molecular Mass: The recombinant Rat MSR1/Fc comprises 636 amino acids and has a predicted molecular mass of 69.2 kDa. The apparent molecular mass of the protein is approximately 89 kDa in SDS-PAGE under reducing conditions.
• Formulation: Lyophilized from sterile PBS, pH7.4.
  1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
  2. Please contact us for any concerns or special requirements.
• SDS-PAGE: MSR1 / SCARA1 protein

MSR1 / SCARA1 Protein Usage Guide

• Storage: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

MSR1 / SCARA1 Protein Description

Macrophage scavenger receptor types I and II, also known as Macrophage acetylated LDL receptor I and II, Scavenger receptor class A member 1, CD204, MSR1 and SCARA1, is a single-pass type I I membrane protein which contains one collagen-like domain and one SRCR domain. Macrophages are distributed in all peripheral tissues and play a critical role in the first line of the innate immune defenses against bacterial infection by phagocytosis of bacterial pathogens through the macrophage scavenger receptor 1 (MSR1). MSR1 / SCARA1 is one of the membrane glycoproteins implicated in the pathologic deposition of cholesterol in arterial walls during atherogenesis. Two types of receptor subunits exist. These receptors mediate the endocytosis of a diverse group of macromolecules, including modified low density lipoproteins (LDL). MSR1 / SCARA1 is also involved in chronic inflammation which is a risk factor for prostate cancer. MSR1 1 gene was identified as a candidate susceptibility gene for hereditary prostate cancer and as a risk factor for sporadic prostate cancer.

References

1. Wang L. et al., 2003, Nat Genet. 35 (2): 128-9.
2. Chen Y.C. et al., 2008, Cancer Epidemiol Biomarkers Prev. 17 (4): 1001-3.
3. Shirato K. et al., 2009, Pflugers Arch. 459 (1): 93-103.
4. Sun J. et al., 2006, Prostate. 66 (7): 728-37.